112257-12-2, tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of Example 53, N-[(2R)-i-amino-3-(4-cyanophenyl)propan-2-yl]- 2-chloro-5-[5 -( { [(1 R)- 1 -(4-methylphenyl)ethyl] amino }methyl)-2-furyl]benzamide, 125 mg (0.237 mmol) in acetonitrile (5.0 mL) was added triethylamine, 50 iL (0.356 mmol,1.5 eq) and tert-butyl 4-(bromoacetyl)piperazine-1-carboxylate, 95 mg (0.31 mmol, 1.3 eq.). The mixture was stirred at r.t, for 24 h, The mixture was diluted with ethyl acetate (20 mL) and the organic layer was washed successively with aq. sat, sodium hydrogen carbonate, water, brine, dried over sodium sulfate and concentrated. The residue was purified by preparative TLC (eluent: dichloromethane/ ammonia 7N in methanol, 97/3)to give an impure fraction that was purified by preparative TLC (eluent:dichloromethane/ ammonia 7N in methanol, 97.5/2.5) to give the pure product, 52 mg(29%) as an off-white solid.LC-MS (Method 1): R = 2,50 mm; MS (ES+): mlz = 753/755 (M+H), 535/537 (M+H21 8) ?H-NMR (500 MHz, DMSO-d6) d [ppm] = 1.25 (d, 3H), 1.40 (s, 9H), 2.27 (s, 3H), 2.65-2.72 (m, 2H), 2.80 (dd, 1H), 3.05 (dd, 1H), 3.24-3.35 (m, 5H), 3.35-3,48 (m, 5H),3.50 & 3.58 (2 d, AB, 2H), 3.70 (m, 1H), 4.27 (m, 1H), 6.32 (d, 1H), 6.92 (d, 1H), 7.12 (d, 2H), 7.24 (d, 2H), 7.44-7.51 (m, 4H), 7.66 (dd, 1H), 7.76 (d, 2H), 8.40 (d, 1H)., 112257-12-2
The synthetic route of 112257-12-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BERGER, Markus; HUeBNER, Jan; TER LAAK, Antonius; GORJANNACZ, Matyas; FERNANDEZ-MONTALVAN, Amaury Ernesto; RODESCHINI, Vincent; ROCHE, Didier; (248 pag.)WO2017/93272; (2017); A1;,
Piperazine – Wikipedia
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