Analyzing the synthesis route of 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

Take 5.12 L of pyridine in a 30 L reactor,640 g of the 3- (2-pyrrolo [2,3-b] pyrazine-3-ethynyl) -4-methylbenzoic acid obtained in Example 6,575 g of 3-trifluoromethyl-4- (4-methylpiperazin-1-ylmethyl) aniline and 484 g of EDCI,30 reaction 24h.After the reaction,The solvent was distilled off under reduced pressure,After adding 4.5L DMF dissolved,Slowly poured into 10L of water,filter,Drying gave the title compound,Yield 92%., 694499-26-8

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference：
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Wang Yong; Sha Xiangyang; Li Erna; Zhao Liwen; (10 pag.)CN106632347; (2017); A;,
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