With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
The compound (S) -5- (1 – ((tert-butoxycarbonyl) amino) ethyl) -2- (3- (cyclopropylmethoxy) -4-(difluoromethoxy) phenyl ) -oxazole-4-carboxylic Acid (250mg, 0.53mmol), 1-Boc-2- methylpiperazine(130mg, 0.64mmol), 1- ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride Salt (155mg, 0.80mmol)and N- hydroxy-7-aza-benzotriazole (182mg, 1.33mmol) was dissolved in dichloromethane (15mL), and 0 Cunder conditions to this solution was added dropwise N, N- diisopropylethylamine (0.37mL, 2.14mmol), stirredat room temperature 5h, was added water (10mL × 2)Washing the organic phase was dried over anhydrous Na2 SO 4, the solvent was removed concentrate was subjected to column chromatography (eluent: Petroleumether/ EtOAc (V / v) = 2/1), to give 215mg of colorless viscous material, yield: 60%.
120737-78-2, 120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
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