With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
To a stirred solution of trans-4-chloro-3-nitrocinnamic acid (1.50 g, 6.59 mmol) and 1-acetylpiperazine (0.89 g, 6.94 mmol) in 20 ML of DMF at room temperature was added EDAC (1.4 g, 7.30 mmol).The mixture was then stirred at room temperature for 2 hours. TLC indicated the complete consumption of the acid.Water was then added to quench the reaction and to precipitate out the product.Cinnamide was then collected through filtration and washed with cold water.The light yellow product was dried in vacuum oven overnight at 40 C. to give 2.04 g (6.03 mmol, 91.6%) of the title compound.
13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Abbott Laboratories; US2004/116518; (2004); A1;,
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