Big data shows that 171504-98-6 is playing an increasingly important role.
171504-98-6, Methyl 1,4-Bis(Boc)-2-piperazinecarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 142: (+/-)-1 ,4-bis(1 ,1-dimethylethyl) 2-methyl 2-methyl-1 ,2,4- piperazinetricarboxylate; In a 500ml round-bottomed flask, 12 g of intermediate 141 (34.8 mmole) were dissolved in 240 ml. of THF to give a colourless solution. 38.3 ml. of LiHMDS 1 M in THF (38.3 mmole) were added dropwise to the solution keeping the mixture to -78C. The reaction was allowed to stir at this temperature for 1 h. 2.40 ml. of iodomethane (38.3 mmole) were added dropwise at -78C and the reaction was allowed to stir at this temperature for 1 h. The mixture was warmed to -200C and it was allowed to react at this temperature for 2 h. The reaction was almost complete and was cooled to -78C and 12 ml. of LiHMDS 1 M in THF (12 mmole, 1 M sol. In THF) and 1.2 mL of iodomethane (19 mmole) were added successively at this temperature. Then the mixture was warmed to -200C and after 1.5 h a TLC control showed then the reaction was finished. The mixture was quenched at 00C with 150 mL of a saturated solution of ammonium chloride. Then the mixture was allowed to reach RT. The two phases were separated and the aqueous was extracted with 2×200 mL of AcOEt. The resulting organic layer was dried over Na2SC>4, filtered and evaporated under reduced pressure to obtain 12.2 g of desired product as a crude oil. UPLC-MS [Acquity UPLC BEH C18, 50×21 mm, 1.7 mum, Mobile phases: A: H2O +0.1% HCOOH/B: MeCN+0.06% HCOOH; Gradient: t=0 min: 97%A, 3% B t= 0.1 min 94%A, 6%B t=0.6min 30%A, 70%B t=1.10min 1%A, 99%B t=1.45 min 97%A, 3%B t=1.50min 97%A ,3%B flow rate: 1 mL/min, UV range wavelength 210-350nm] R1 = 0.80 min , m/z (ES): 359 [M+H]+., 171504-98-6
Big data shows that 171504-98-6 is playing an increasingly important role.
Reference：
Patent; GLAXO GROUP LIMITED; WO2008/148853; (2008); A1;,
Piperazine – Wikipedia
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