129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of 1-tert-butyl 3-methyl piperazine-1, 3-dicarboxylate (1.0 g, 4.1 mmol) , nickel chloride (640 mg, 4.9 mmol) and anhydrous ethanol (10 mL) was added sodium borohydride (380 mg, 10.0 mmol) at 0 . The mixture was stirred for 4 h and quenched with ice-water (5 mL) . The mixture was adjusted with concentrated hydrochloric acid to pH 1. After the mixture was clear, a NaOH aqueous solution (1.0 M) was added to adjust pH 10. The resulting mixture was extracted with EtOAc (10 mL × 3) . The combined organic layers were dried over anhydrous Na2SO4 and concentrated to give tert-butyl 3- (hydroxymethyl) piperazine-1-carboxylate as a reseda solid (890 mg, 83) .1H NMR (400 MHz, CD3OD) : delta ppm 3.99-4.02 (m, 1H) , 3.90-3.93 (m, 1H) , 3.48-3.54 (m, 2H) , 2.96-3.00 (m, 1H) , 2.83-2.93 (m, 1H) , 2.66-2.72 (m, 2H) , 2.56-2.66 (m, 1H) , 1.48 (m, 9H) and MS-ESI: m/z 217.10 [M+H] +., 129799-08-2
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Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
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