With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.
130 g of compound C and 89.9 g of material D were added to the reaction flaskCounted as the molar ratio to match the delivery ratio,Compound C was purified) and 1.8 L of methanol,Under the protection of nitrogen, the temperature was stirred to reflux, 1.5-2h after the reaction solution was dissolved, stirring 9-10h, the sample solution for TLC, no compound C was observed, slightly cool to the reaction system by adding 22g25% aqueous ammonia (mass percentage), continue to warm up to reflux for 2h, there is a clear yellow particles solid precipitation, every 2h sampling for HPLC, detected to the compound E residue of less than 0.1%; the end of the reaction slow mixing speed to room temperature (15-20 ), Filtered, 1.2L of water to wash the filter cake, fully dried to dry the dark yellow powder solid, 60 C blast dry to give compound F 170.5g dark brown powder. The molar yield of the Nidanibu free base (Compound F) was 89%, the purity was 99.8%, and the maximum single impurity was less than 0.1%.
262368-30-9, As the paragraph descriping shows that 262368-30-9 is playing an increasingly important role.
Reference：
Patent; Changzhou Jiade Pharmaceutical Technology Co., Ltd.; Wang Zifu; (7 pag.)CN107011241; (2017); A;,
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