With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.350684-49-0,tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
General procedure: The mixture of compound 10a-10e (3.24 mmol), compound 9(1.04 g, 3.4 mmol), Pd(OAc)2 (0.11 g, 0.5 mmol), Xantphos (0.28 g,0.5 mmol), and K3PO41.38 g, 6.48 mmolin DMF (8 mL) was heated 22 h at 125 C under argon followed by cooling to roomtemperature.The mixture was extracted with dichloromethane(20 mL x 3), the combined organic phase was washed with water(15mL x 2), dried over anhydrous Na2SO4 and concentrated toafford the crude product. The crude product was purified by columnchromatography to obtain compounds 11a-11e. 4.1.6.1. Tert-butyl 4-(4-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin -2-yl)amino)benzoyl)piperazine-1-carboxylate(11a). Yield 62%. MP: 227-228 C. 1H NMR (400 MHz, DMSO-d6)delta 11.64 (s, 1H), 9.73 (s, 1H), 8.77 (dd, J = 17.2, 4.4 Hz, 2H), 8.28 (s, 1H),7.78 (d, J = 8.8 Hz, 3H), 7.56-7.52 (m, 1H), 7.36 (d, J = 8.4 Hz, 2H),7.17 (t, J = 7.2 Hz, 1H), 3.50-3.36 (m, 8H), 2.83 (d, J = 4.4 Hz, 3H),1.42 (s, 9H).13C NMR (100 MHz, DMSO-d6) delta169.32, 168.87, 157.39,155.07, 154.53, 153.83, 141.78, 139.15, 131.45, 127.99, 122.13, 121.58, 121.01, 118.47, 105.80, 79.16, 43.56, 42.90, 28.02, 26.31., 350684-49-0
350684-49-0 tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate 2763355, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Su, Yue; Li, Ridong; Ning, Xianling; Lin, Zhiqiang; Zhao, Xuyang; Zhou, Juntuo; Liu, Jia; Jin, Yan; Yin, Yuxin; European Journal of Medicinal Chemistry; vol. 177; (2019); p. 32 – 46;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics