Downstream synthetic route of 4-(4-Methylpiperazin-1-ylmethyl)phenylamine

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.

70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-82-4, STEP-1: To the solution of compound 1 (16.7 g, 73 mmol) and NaHCO3 (18.5 g, 219 mmol) in anhydrous DMF, was added sodium chloroacetate 2 (12.8 g, 109.5 mmol). After the addition, the mixture was stirred at 75 C. for 2 h, and to the resultant mixture, was added compound 3 (15 g, 73 mmol) in portion at the same temperature and the solution was stirred for 4 h. The mixture was cooled to room temperature and poured into ice water. The resultant precipitate was filtered, washed with water and dried to give target compound. Quantity: 20 g; yellow solid; yield: 75%.

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.

Reference:
Patent; Burlison, Joseph A.; Zhang, Shijie; Ying, Weiwen; Chimmanamada, Dinesh U.; Song, Minghu; Chae, Junghyun; Schweizer, Stefan M.; US2010/113447; (2010); A1;,
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