With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.
To the solution of product of Step A (690 mg, 2.44 mmol) in DCM (10 mL) was added 1- ethylpiperazine (279 mg, 2.44 mmol) followed by Et3N (247 mg, 2.44 mmol). The solution was stirred at room temperature for 4 hours. TLC (PE/EA = 5/1) showed the reaction was completed. The resulting solution was concentrated and the residue (770 mg, yield: 99%) was used in next step directly. MS: IVJIe 318 (M+1)., 5308-25-8
The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; BEIGENE, LTD.; ZHOU, Changyou; ZHANG, Guoliang; WO2014/206343; (2014); A1;,
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