With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182618-86-6,1-Boc-4-(4-Nitrophenyl)piperazine,as a common compound, the synthetic route is as follows.
Add 1 g of crude I-i (32.6 mmol) to a 500 mL single-necked flask. 1.0 g of FeO(OH)/C catalyst and 100 mL of 95% ethanol, heated to reflux. Slowly add a mixture of 10 mL of hydrazine hydrate and 20 mL of 95% ethanol. The disappearance of the starting material by TLC (methanol: chloroform = 1:15). The filter cake was washed twice with hot ethanol (30 mL × 2). The solvent was evaporated under reduced pressure to give a white solid. It was dried under vacuum to give (I-j) 7.86 g, yield: 87.1%. The product was directly fed to the next reaction without further purification.
182618-86-6, As the paragraph descriping shows that 182618-86-6 is playing an increasingly important role.
Reference：
Patent; China Pharmaceutical University; Wang Yue; Lu Shuai; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (26 pag.)CN109970717; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics