With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216144-45-5,4-(4-Methylpiperazin-1-yl)benzylamine,as a common compound, the synthetic route is as follows.
Stage 3: 3-isobutyl-1-[4-(4-methylpiperazin-1-yl)benzyl]imidazo[2,1-b]quinazoline-2,5(1H,3H)-dione hydrochloride[4-(4-methylpiperazin-1-yl)benzyl]amine (194 mg) is added to methyl 2-(2-chloro-4-oxoquinazolin-3(4H)-yl)-4-methylpentanoate (150 mg) in anhydrous THF (2 mL) placed in a ?Biotage? reaction tube. The tube is sealed with a cap, stirred at ambient temperature for 1 hour then placed in a ?Biotage? micro-wave and heated under magnetic stirring at 150 C. for 1 hour. The mixture is concentrated under reduced pressure at 40 C. Purification by flash chromatography on silica gel (eluent: dichloromethane/methanol 95:5) produces the expected compound in the form of the free base. The corresponding hydrochloride salt is formed by adding a 1N HCl solution in ethyl ether to the solution of the free base in ethyl acetate. The precipitate obtained is filtered and dried in order to produce the expected hydrochloride compound (145 mg, 60% yield from Stage 2).MS/LC: calculated MM=445.6; m/z=446.3 (MH+)NMR (1H, 400 MHz, DMSO-d6): delta0.81 (m, 6H), 1.80 (m, 1H), 2.01 (m, 2H), 2.77 (s, 3H), 3.06 (m, 4H), 3.40 (m, 2H), 3.77 (m, 2H), 4.79 (AB, 1H), 4.81 (AB, 1H), 4.93 (t, 1H), 6.96 (AB, 1H), 7.32 (AB, 1H), 7.42 (t, 1H), 7.57 (AB, 1H), 7.76 (t, 1H), 8.08 (AB, 1H), 10.96 (s, 1H)., 216144-45-5
As the paragraph descriping shows that 216144-45-5 is playing an increasingly important role.
Reference：
Patent; SOCIETE DE CONSEILS DE RECHERCHES ET D’APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.); US2010/144714; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics