161357-89-7, 1-(Methylsulfonyl)piperazine hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of intermediate 6 (200 mg, 0.53 mmol ) and 1-(methylsulfonyl)piperazine hydrochloride (87 mg, 0.53 mmol) in dry toluene (5 ml_), sodium tert butoxide (150 mg, 1.6 mmol) was added at RT and the resulting solution was flushed with nitrogen for 10 min. BINAP (66 mg, 0.1 mmol), Pd (dba (98 mg, 0.1 mmol) were added and the reaction mixture was flushed again with nitrogen for 10 min. It was then stirred at 100 C overnight. After completion of the reaction, the reaction mixture was diluted with EtOAc (20 mL) and filtered through celite pad. The filtrate was concentrated under vacuum and resulting crude product was purified by flash chromatography (Eluent: 47% EtOAC in pet ether) to afford the title compound. Yield: 5% (1 1 .3 mg, off-white solid). 1H NMR (400 MHz, DMSO-cfe): d 7.09 (d, J = 8.4 Hz, 2H), 6.92-6.90 (m, 3H), 6.85 (d, J = 2.0 Hz, 1 H), 6.82-6.80 (m, 1 H), 4.22 (s, 4H), 3.61 (d, J = 12.8 Hz, 1 H), 3.23-3.20 (m, 10H), 2.92 (s, 3H), 2.1 1 -2.06 (m, 2H), 1.72-1.68 (m, 2H), 1.56-1.48 (m, 1 H). LCMS: (Method A) 458.1 (M +H), Rt.1.570 min, 99.4% (Max). HPLC: (Method A) Rt. 3.038 min, 99.5% (Max), 99.4% (220 nm).
161357-89-7, 161357-89-7 1-(Methylsulfonyl)piperazine hydrochloride 16265612, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; RAKESH, Paul; (338 pag.)WO2020/39027; (2020); A1;,
Piperazine – Wikipedia
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