With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.
To a stirred solution of XX (0.400 g, 1.13 mmol) in DMF (4 mL), compound V (0.464 g, 1.69mmol) was added to reaction mass then HATU (0.861 g, 2.26 mmol) and DIPEA (0.462 g, 3.39 mmol) wasadded to the reaction mass at RT. Then RM was allowed to stir at RT overnight, after completion ofreaction, compound was extracted with ethyl acetate (30 mL x 3) and brine washing was given to organiclayer and dried over Na2SO4 and evaporated upon vacuum, and purified though reverse phase HPLC toobtain compound 9 (0.060 g, 9%).LCMS: 607 [M+1]+1HNMR (400 MHz, DMSO) delta 10.5 (s, 1H), 8.2 (s, 1H), 8.0 (d, 2H),7.9 (d, 1H), 7.8 (d, 1H), 7.6 (m, 2H),7.5 (t, 2H), 7.2 (d, 2H), 7.0 (d, 1H), 3.5 (s, 2H), 3.2 (s, 3H), 2.5 (m, 8H), 2.3 (s, 3H), 2.2 (s, 3H).
694499-26-8, 694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
Piperazine – Wikipedia
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