68104-63-2, 4-(Piperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
68104-63-2, Preparation 23 tert-butyl 4-(4-cyanophenyl)piperazine-1-carboxylate 4-(piperazin-1-yl)benzonitrile (0.7g, 3.74mmol) was dissolved in a mixture of dioxane/water (15ml/7ml), then 1 N solution of NaOH was added (5.2ml) and finally BOC2O (0.82g, 3.78mmol). The reaction mixture was stirred at r.t. for 2h. The solvent was concentrated and the residue redissolved in water and the pH adjusted to 7 by adding 2N HCl. The aqueous layer was extracted with chloroform and the organic layer washed with brine, dried over magnesium sulphate and evaporated under reduced pressure to give 1 g of the desired compound (yield=93%) as a white solid. LRMS: m/z 288 (M+1)+ Retention time: 6.33 min (Method B) 1H NMR (300 MHz, CDCl3) delta ppm: 1.49 (s, 9H), 3.33-3.35 (m, 2H), 3.57-3.59 (m, 2H), 6.84-6.87 (m, 2H), 7.50-7.53 (m, 2H).
68104-63-2 4-(Piperazin-1-yl)benzonitrile 2733995, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Laboratorios Almirall, S.A.; EP2202232; (2010); A1;,
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