With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
1-fluoro-4-nitrobenzene (1.460 g, 10.4 mmol) and potassium carbonate (4.29 g, 31.0 mmol) were suspended inanhydrous DMF (10 mL) . (S)-tert-butyl 3- (hydroxymethyl)piperazine-1-carboxylate (2.35 g, 10.9 mmol) was added and the mixture was heated at 90 C for 21 h. After cooling the mixture was partitioned between brine/water (100 mL) and ethyl acetate (25 mL) . Theaqueous layer was separated and further extracted with ethyl acetate (3 x 25 mL) . The combined ethyl acetate fractions were washed with brine/water (1:1, 4 x 25 mL), dried (anhydrous sodium sulfate), filtered and reduced in vacuo. The resulting residue was purified by silica gelchromatography (gradient 25-100% ethyl acetate incyclohexane) to afford the title compound (0.99 g, 28.4%) . ?H NMR (400 MHz, CDC13) : 3 8.12 (d, 2H), 6.83 (d, 2H),4.20-4.46 (m, 1H), 4.02-4.14 (m, 2H), 3.48-3.76 (m, 3H),3.08-3.30 (m, 3H), 2.86 (br s, 1H), 1.50 (s, 9H) . LCMS(Method C) : = 1.38 mi m/z = 338 [M+H]., 314741-40-7
As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.
Reference：
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics