694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,694499-26-8
3,5-Diiodo-4-methylbenzoic acid (194.0 mg, 0.5 mmol)To the mixture is added SOCl2 (0.73 mL, 10 mmol), and a catalytic amount of DMF is added dropwise,Stir at room temperature for 20 hours. The solution is dried under vacuumIntermediate (3,5-Diiodo-4-methyl-benzoyl chloride)(178.9 mg, 0.44 mmol, 88%, white solid) were obtained.4-[(4-methyl-1-piperidinyl) methyl] -3- (trifluoromethyl) -benzenamine (94.6 mg, 0.35 mmol), N, N-diisopropylethylamine(73 muL, 0.42 mmol), DMAP (1.2 mg, 0.01 mmol) in THF (2.4 mL)Dissolved in water, to which the intermediate (170.7 mg, 0.42 mmol) is added,Stir at room temperature for 2 hours. Add water and extract with ethyl acetate,It concentrated under reduced pressure with an evaporator.The resulting residue is purified by silica gel column chromatography (chloroform: methanol = 10: 1) to give compound 1(180.0 mg, 0.28 mmol, 80%, pale yellow solid) were obtained.
694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Kyoto University; Arkray Corporation; Saji, Hideo; Kimura, Hiroyuki; Matsuda, Hirokazu; Nakanishi, Shuichi; (27 pag.)JP2019/64986; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics