694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline (2.27 g, 8.3 mmol), 3-iodo-4-methyl-benzoyl chloride (10 mmol), 15 ml tetrahydrofuran, and 10 ml triethylamine were added into a reactor and stirred at room temperature for 4 hours. After completion of the reaction, the resultant was washed with a saturated NaHCO3 solution, extracted with ethyl acetate and water, washed with a saturated NaCl solution, dried over anhydrous Na2SO4. The solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography, to give a yellow oily matter. 1H NMR (500 MHz, CDCl3) delta: 8.39 (s, 1H, N-H), 8.29 (s, 1H, Ar-H), 7.88 (d, 1H, Ar-H), 7.86 (s, 1H, Ar-H), 7.75 (d, 1H, Ar-H), 7.73 (d, 1H, Ar-H), 7.28 (d, 1H, Ar-H), 3.62 (s, 2H, PhCH2), 2.60 (b, 8H, 4*-CH2), 2.47 (s, 3H, -CH3), 2.31 (s, 3H, -CH3)., 694499-26-8
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Reference：
Patent; Nanjing Sanhome Pharmaceutical Co., Ltd.; Wang, Yong; Zhao, Liwen; Zhang, Wenping; Chen, Hongyan; Bi, Sheng; Gao, Yiping; Chen, Hongbin; Liu, Yang; Xu, Xin; Zhang, Cang; US2015/152088; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics