1228780-72-0, 1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1228780-72-0, Combined 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzonitrile (6.6 g) and 1-((4’chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[ 1,1 ‘-biphenyl]-2-yl)methyl)piperazine (7. 7 g) intetrahydrofuran (200 mL). To the reaction mixture sodium tert. Butoxide (6.0 g) and ( 4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine (A-phos) (445 mg) were added at30C and degassed with Argon for 30 minutes under stirring at the same temperature.Tris(dibenzylideneacetone)dipalladium(O)-chloroform adduct (870 mg) was added anddegassed for 5 minutes at 30C. The reaction mixture was heated to 70C and stirred for15 hours at the same temperature. The reaction mixture was cooled and filtered on celitebed. The celite bed was washed with tetrahydrofuran (2 x 50 mL) and evaporated thesolvent in the filtrate. The crude product was dissolved in the ethyl acetate (100 mL) andwashed with water (100 mL), saturated sodium bicarbonate solution (70 mL), 10%solution of L-cysteine (100 mL) and brine solution (60 mL). The organic solution wasdried over sodium sulfate and evaporated the solvent under reduced pressure. The crudeproduct was purified by column chromatography using 100-200 mesh silica gel and 40-50% ethyl acetate-hexane as eluent to obtain the title compound as yellow solid. Yield:9.5 g; Purity by HPLC: 98.30%
The synthetic route of 1228780-72-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; DR. REDDY?S LABORATORIES LIMITED; PEDDIREDDY, Subba Reddy; KOTTUR, Mohan Kumar; JURUPULA, Ramprasad; BAIG, Mohammed Azeezulla; CHAKKA, Ramesh; THIPPARABOINA, Rajesh; PEDDY, Vishweshwar; RAO, Pallavi; ORUGANTI, Srinivas; DAHANUKAR, Vilas Hareshwar; (88 pag.)WO2017/212431; (2017); A1;,
Piperazine – Wikipedia
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