Month: May 2021

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

This was obtained by stirring MA2-004 (0.698 g) and 4-(4-i170911-92-9, As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.

Reference£º
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (293 pag.)WO2017/66428; (2017); A1;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27561-62-2,Cyclohexyl(piperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

General procedure: 10mM sulfochloride hydrochloride was suspendedin 50 ml ethylacetate and 11mM amine component wasadded with stirring. 2.8 ml triethylamine dissolved in 10 ml ethylacetatewas dropped in with stirring and kept stirring overnight atambient temperature. The reaction mixture was extracted threetimes with water, the organic phase was dried over sodium sulfatefiltered, and then evaporated to dryness. For cases in which an oilyproduct was obtained, the residue was treated with diisopropylether., 27561-62-2

As the paragraph descriping shows that 27561-62-2 is playing an increasingly important role.

Reference£º
Article; Singh, Vinayak; Pacitto, Angela; Donini, Stefano; Ferraris, Davide M.; Boros, Sandor; Illyes, Eszter; Szokol, Balint; Rizzi, Menico; Blundell, Tom L.; Ascher, David B.; Pato, Janos; Mizrahi, Valerie; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 309 – 329;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Benzyl carbonochloridate (6.43 mL, 45.03 mmol) was added to a solution of 1-tert-butyl 3-methyl piperazine-1,3-dicarboxylate (10 g, 40.94 mmol) and DIEA (14.30 mL, 81.87 mmol) in THF (100 mL) at 5C, and the mixture was stirred at room temperature for 14 hr. The reaction mixture was added to water and ethyl acetate. The organic layer was washed with aqueous ammonium chloride solution, dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (solvent gradient; 5?20% ethyl acetate/hexane) to give 1-benzyl 4-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate (16.2 g, 42.8 mmol, 105%) as white crystals. 1H NMR (300 MHz, CDCl3):delta 1.44(9H,s), 2.63-3.48(3H,m), 3.74(3H,s), 4.11(2H,s), 4.44-4.86(2H,m), 5.08-5.26(2H,m), 7.22-7.42(5H,m).

129799-08-2, The synthetic route of 129799-08-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; YAMAMOTO, Satoshi; SHIRAI, Junya; ODA, Tsuneo; IMADA, Takashi; KONO, Mitsunori; SATO, Ayumu; TOMATA, Yoshihide; OCHIDA, Atsuko; ISHII, Naoki; SASAKI, Yusuke; FUKASE, Yoshiyuki; YUKAWA, Tomoya; FUKUMOTO, Shoji; (200 pag.)EP3192791; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

66-1) 1-[2-(4-Fluorobenzenesulfonylamino)ethyl]-4-(t-butoxycarbonyl)piperazine The 1-(2-aminoethyl)-4-(t-butoxycarbonyl)piperazine (2.01 g) obtained in Example 58 and 4-fluorobenzene sulfonylchloride (2.05 g) were dissolved in tetrahydrofuran (20 ml), and triethylamine (2.4 ml) was added thereto, and the mixture was stirred overnight at room temperature. Water (50 ml) was added to the reaction mixture which was then extracted with ethyl acetate, and the organic layer was washed with water, dried, and evaporated. The residue was purified by Cromatorex NH silica gel column chromatography (hexane/ethyl acetate system), whereby the title compound (2.61g, 77percent) was obtained as a colorless oil., 192130-34-0

As the paragraph descriping shows that 192130-34-0 is playing an increasingly important role.

Reference£º
Patent; Eisai Co., Ltd.; EP1099692; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

Compound BB-17-1 (7.0g, 31.78mmol) was dissolved in dilute hydrochloric acid (6M, 150mL) with stirring until homogeneous under nitrogen protectionskid slowly dropwise a solution of sodium nitrite (4N, 30 mL), then stirred at room temperature about one hour, 100mL of water was added with ethylacetate and extracted (100mL ¡Á 3).The combined organic phases were washed with saturated brine (20 mL), dried over anhydrous sodium sulfate, and under reduced pressure to removethe solvent, the resulting target compound BB-17-2 (7.5g, yield: 66%), was used directly in the next step without further purification.

31166-44-6, The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Changzhou Yin Sheng Pharmaceutical Co., Ltd.; Sichuan University; Zhang, Yang; Fu, Zhifei; Li, Jian; Chen, Shuhui; Wei, Yuquan; Tao, Xin; (65 pag.)CN105732602; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

General procedure: I-c (0.6 g, 2.8 mM), 2-methoxyethanol (1.3 g, 17 mM) and sodium hydride (0.1 g, 2.8 mM, 60percent) in ethanol were heated to reflux for 5 h. The mixture was evaporated in vacuo and purified by silica gel column chromatography to get I-d-02 (0.6 g, 78.5percent) as a white solid., 934-98-5

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Article; Wang, Lu; Zhang, Qing; Zhu, Gaoyuan; Zhang, Zhimin; Zhi, Yanle; Zhang, Li; Mao, Tianxiao; Zhou, Xiang; Chen, Yadong; Lu, Tao; Tang, Weifang; European Journal of Medicinal Chemistry; vol. 130; (2017); p. 86 – 106;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55276-43-2,1-Methanesulfonylpiperazine,as a common compound, the synthetic route is as follows.

Example 1; This Example illustrates the preparation of N- (3-phenyl-3- [4- METHANESULPHONYLPIPERAZIN-1-YL] PROPYL)-4- [2- (4-METHANESULPHONYLPHENYLSULPHONYL) ethyl] – piperidine (Compound No. 8, Table I). N- (3-Phenyl-3-chloropropyl)-4- [2- (4-methanesulphonylphenylsulphonyl) ethyl] – piperidine (prepared according to Method D; 180mg) was added to a solution of N- methanesulphonylpiperazine (61mg) and triethylamine (0. 102ML) in dichloromethane (10ML) and the mixture was allowed to stand at room temperature for 16 hours. The reaction mixture was poured onto a 20g silica Bond Elut eluted with a solvent gradient (ethyl acetate-25% methanol/ethyl acetate). The title compound was obtained, yield 67mg, MHF 612. NMR (CDC13) : 1.6-1. 8 (m, 7H), 2.2-2. 6 (m, 9H), 2.7 (m, 1H), 2.75 (s, 3H), 3.2 (m, 11H), 3.45 (m, 1H), 7.2 (d, 2H), 7.3 (m, 3H), 8.2 (m, 4H)., 55276-43-2

55276-43-2 1-Methanesulfonylpiperazine 709161, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WO2004/56773; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 74 (2-Cyclopent-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone Following procedure E, (2-Cyclopent-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone is prepared from 2-cyclopent-1-enyl-5-methanesulfonyl-benzoic acid (Example H) and 1-(4-trifluoromethyl-phenyl)-piperazine: colourless foam, MS (ISP): 479.5 (M+H+).

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; Alberati-Giani, Daniela; Jolidon, Synese; Narquizian, Robert; Nettekoven, Matthias Heinrich; Norcross, Roger David; Pinard, Emmanuel; Stalder, Henri; US2005/59668; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

General procedure: To a solution of 2 (0.6 mmol) in MeOH/H2O/DMSO=2:1:1(4 mL)was added sodium hydroxide (6 mmol). The solution was warmed to 45 C, after being stirred for overnight, the mixture allowed to cool, and the MeOH was removed by rotary evaporation. To the resultant slurry 1M HCl was added, and the pH was adjusted to 4. Subsequently, the mixture was filtered and washed thoroughly with water, dried to afford a white solid, which was used without additional purification. A mixture of above acid (0.3 mmol), HOBt (0.36 mmol), EDCI (0.36 mmol)were dissolved in dry DMF(3 mL), and stirred for 20 min. Then, amine(0.6 mmol) were added, the mixture was stirred for overnight, diluted with EtOAc, washed with water (30 mL¡Á5), dried over anhydrous Na2SO4, filtered and evaporated under-reduced pressure. The crude product was purified by silica gel column chromatography to afford the corresponding product 3-26.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xiao, Xiao; Xu, Mei; Yang, Chao; Yao, Yao; Liang, Li-na; ED Chung, Philip; Long, Qun; Zacksenhaus, Eldad; He, Zhixu; Liu, Sheng; Ben-David, Yaacov; Bioorganic and Medicinal Chemistry; vol. 26; 23-24; (2018); p. 6096 – 6104;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To the stirred solution of 3-(3-oxo-2H-benzo[b][1,4]thiazin-4(3H)-yl)propanoic acid (100mg, 0.448 mol) in DMF, N-phenyl piperzine derivatives (0.538 mol) or 3-(4-phenylpiperazin-1-yl)propan-1-amine derivatives (0.538 mol) was added at room temperature, followed by the addition of EDC:HCl (102 mg) and HOBt (60.5 mg), the stirring was continued for 12h. After completion of the reaction (TLC analysis), small amount of ice cold water (10 mL) was added to the reaction mixture and then extracted with chloroform (2 x 10 mL). The chloroform layer was separated, dried over Na2SO4 and evaporated under vacuum to give corresponding derivatives 8a-i and 10a-g in good yields., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Venkatesh, Ramineni; Kasaboina, Suresh; Bidayat, Deepthi; Nikhil Kumar; Jain, Nishant; Tangeda, Saritha Jostna; Bantu, Rajashaker; Janardhan, Sridhara; Nagarapu, Lingaiah; Bioorganic and Medicinal Chemistry Letters; vol. 27; 2; (2017); p. 354 – 359;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics