Month: May 2021

288251-87-6, tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-(2-Cyano-4-nitro-phenyl)-piperazine-l -carboxylic acid tert-butyl ester (587 mg, 1.77 mmol) was dissolved in methanol (50 mL) and to this solution was added ammonium chloride (945 mg, 17.66 mmol) and zinc (1155 mg, 17.66 mmol). The mixture was magnetically stirred for 3 hr and the mixture was filtered through a pad of celite. The solids were rinsed with methanol and the combined filtrate was concentrated to a yellow solid. This crude intermediate was dissolved in ethyl acetate (400 mL) and the resulting solution was washed with water (400 mL) and brine (200 mL). The organic layer was collected, dried over sodium sulfate, and concentrated to give 4-(4-amino-2-cyano- phenyl)-piperazine-l-carboxylic acid tert-butyl ester that was used in the next step without further purification., 288251-87-6

The synthetic route of 288251-87-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/141976; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288251-87-6,tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,288251-87-6

To a stirred solution of 567 tert-butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate (2.0 g, 6.021 mmol, 1.0 eq) in 6 EtOH (30 mL) was added Fe(0) (1.0 g, 18.064 mmol, 3 eq) and a solution of 67 NH4Cl (644 mg, 12.042 mmol, 2 eq) in 7 water (30 mL) at rt. The resulting mixture was heated at 90 C. for 1 hr. The progress of reaction was monitored by LCMS. The reaction mixture was filtered through celite the residue was washed with EtOH (50 mL). The filtrate was concentrated and the residue was dissolved in 19 EtOAc (100 mL), washed with water (2¡Á100 mL), dried over Na2SO4, and concentrated to afford the desired compound, 570 tert-butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate (1.77 g, 88.5%). (0598) LCMS: 303.2 [M+1]+

As the paragraph descriping shows that 288251-87-6 is playing an increasingly important role.

Reference£º
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

84477-72-5, 2,2-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

84477-72-5, To a solution of 2,2-dimethylpiperazine (1.50 g, 13.1 mmol) in CH2Cl2 (119 mL) at 0 C was added BOC2O (2.8 mL, 12 mmol) and the resulting mixture was stirred at RT for 14 h. The mixture was concentrated under reduced pressure and taken on to the next step without purification

The synthetic route of 84477-72-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; CHEMPARTNER CORPORATION; DI FRANCESCO, Maria, Emilia; JONES, Philip; CARROLL, Christopher, Lawrence; CROSS, Jason, Bryant; JOHNSON, Michael, Garrett; LIVELY, Sarah; (187 pag.)WO2018/218197; (2018); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

185110-19-4, 2-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: (+/-)-Methyl {3-[4-(trifluoromethyl)phenyl]piperazin-l-yl} acetate; A mixture of the piperazine described in Step 2 above (2.1g, 9mmol), methyl bromoacetate (ImL, 9mmol) and potassium carbonate (2.4g, 18mmol) in acetonitrile (3OmL) was stirred overnight at room temperature. The mixture was filtered, evaporated and purified on silica using 25-50% ethyl acetate in z’s¡ã-hexane as eluant.1H NMR (500MHz, CDCl3): delta 2.22 (IH, t, J 10.6), 2.37-2.43 (IH, m), 2.93 (2H, t, J 9.4), 3.10- 3.17 (2H, m), 3.26 (2H, s), 3.72 (3H, s), 7.52 (2H, d, J 8.1), 7.58 (2H, d, J 8.2).

185110-19-4, The synthetic route of 185110-19-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; MERCK & CO., INC.; WO2007/125364; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2759-28-6,1-Benzylpiperazine,as a common compound, the synthetic route is as follows.

Synthesis of 1-(1,1-dimethylethoxycarbonyl)4-phenylmethylpiperazine STR30 A solution of 3.4 g (0.024 mole) of 1,1-dimethylethoxy carbonylazide in 5 ml of pyridine was rapidly added to a stirred solution of 1-phenylmethylpiperazine (4.2 g, 0.024 mole) in 5 ml of pyridine. An initial exothermic reaction was noted. The mixture was allowed to stir overnight, diluted with water and the product was extracted with two 50 ml portions of ether. The ether extracts were dried (MgSO4), filtered, and evaporated to yield a yellow oil. Column chromatography (2″ diameter column, 500 g of silica gel, ether eluent) followed by sublimation at 110/0.5 mm returned 5.7 g (86%) of white solid, m.p. 64-73. The solid was dissolved in 50 ml of ether and cooled to -70. The resultant white solid was filtered off to yield 4.5 g (68%) of product, m.p. 71-3. Calc. for C16 H24 N2 O2 (276.38): C, 69.53; H, 8.75; N, 10.14. Found: C, 69.44; H, 8.82; N, 10.15.

2759-28-6, 2759-28-6 1-Benzylpiperazine 75994, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ICI Americas Inc.; US4247549; (1981); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

143673-66-9, (R)-3-Isopropylpiperazine-2,5-dione is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0561] To a solution of compound 4-01-4 (11 g, 70 mmol) in dichloromethane (500 mL) was added trimethyloxonium tetrafiuorob orate (41.7 g, 282 mmol). The slurry was stirred vigorously at 20C under a nitrogen atmosphere for 18 hours. The slurry became a clear solution with very viscous yellow oil settled on the bottom of the flask, then another 10.4 g (70 mmol) of trimethyloxonium tetrafiuorob orate was added and the mixture was stirred at 20C for 24 hours. The mixture was cooled in an ice bath, and 200 g of ice and 100 mL of concentrated ammonium hydroxide solution (30%) were added. The reaction mixture was stirred in an ice bath for 1 hour. The layers were separated and aqueous layer was extracted with DCM (500 mL*2). The combined organic layers were washed with saturated sodium bicarbonate solution (300 mL *2) and brine (300 mL), dried over anhydrous sodium sulfate, filtered through a celite pad, and concentrated under reduced pressure. The residue was purified by column chromatography (petroleum ether to petroleum ether: ethyl acetate = 10: 1) to afford compound 4-01-5 (9 g, 69% yield) as yellow oil.

143673-66-9, As the paragraph descriping shows that 143673-66-9 is playing an increasingly important role.

Reference£º
Patent; CORNELL UNIVERSITY; TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE; LIN, Gang; NATHAN, Carl; KIRKMAN, Laura; ZHAN, Wenhu; MORGAN, Trevor; SATO, Kenjiro; HARA, Ryoma; KAWASAKI, Masanori; IMAEDA, Toshihiro; TOITA, Akinori; OKAMOTO, Rei; YUKAWA, Takafumi; ASO, Kazuyoshi; WONG, Tzu-Tshin; GINN, John, D.; FOLEY, Michael, A.; (296 pag.)WO2019/75259; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

2759-28-6, 1-Benzylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Amine (1 mmol) and di-tert-butyl dicarbonate [(Boc)2O] (1.1 mmol) were placed in a microwave reaction vial. The LG microwave oven MG 555f was programmed to 300 W at 100 C. The reaction was monitored using TLC. After the reaction, ice water was added to the reaction mixture which resulted in the precipitation of the product. The solid product was merely filtered off and washed with excess cold water. The product was pure enough for all practical purposes. For characterization purpose, it was further purified by column chromatography (Neutral Alumina as adsorbent, solvent system: Hexane: Ethyl acetate (7.5:2.5)).

2759-28-6, The synthetic route of 2759-28-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Dighe, Satish N.; Jadhav, Hemant R.; Tetrahedron Letters; vol. 53; 43; (2012); p. 5803 – 5806;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

511254-92-5, (S)-1-Benzyl-2-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

511254-92-5, Step 3: (S)-1-benzyl-2-methyl-4-(1-methylpiperidin-4-yl)piperazine (S)-1-Benzyl-2-methylpiperazine (6.84 g, 36 mmol), 1-methyl-4-piperidone (4.87 g, 43 mmol), and glacial acetic acid (4.32 g, 72 mmol) were successively added to anhydrous ethanol (100 mL). The resultant was stirred for 1 hour, and then cooled to 0C. Sodium triacetoxyborohydride (31.6 g, 150 mmol) was added in portions. The resultant was reacted at room temperature for 6 hours. The solvent was evaporated, and the residue was dissolved by adding ethyl acetate. The resultant was washed by water, dried, concentrated, and purified by silica gel column chromatography to give (S)-1-benzyl-2-methyl-4-(1-methylpiperidin-4-yl)piperazine (7.86 g, 76% yield). MS m/z [ESI]: 288.2 [M+1].

511254-92-5 (S)-1-Benzyl-2-methylpiperazine 28406010, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Chia Tai Tianqing Pharmaceutical Group Co.,Ltd; Centaurus BioPharma Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; XIAO, Dengming; XU, Xinhe; LIU, Xijie; HU, Yuandong; YU, Honghao; LIU, Zhihua; PENG, Yong; SUN, Yinghui; LUO, Hong; KONG, Fansheng; HAN, Yongxin; SUN, Jian; EP2952510; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.623586-00-5,(R)-1-Cbz-3-methylpiperazine,as a common compound, the synthetic route is as follows.

623586-00-5, A mixture of (R)-benzyl 3-methylpiperazine-1-carboxylate (4.8 g, 20.5 mmol) from step (a) above, 1,3-bis(tertbutoxycarbonyl)-2-methylisothiourea (6.5 g, 23 mmol, Aldrich), and triethylamine (3.4 mL, 24.6 mmol, Aldrich) in DCM (140 mL) was added mercury(II)chloride (5.8 g, 21.6 mmol, Aldrich). The reaction mixture was stirred at RT for 16 h. Then, the mixture was filtered and the solid was washed with DCM (2*100 mL). The combined filtrates were concentrated in vacuo and the residue was purified on silica gel using ISCO Combiflash system with DCM/2M methanolic ammonia gradient to give the title compound as a white solid. MS (ESI, positive ion) m/z: 477 (M+1).

The synthetic route of 623586-00-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gore, Vijay Keshav; Ma, Vu Van; Norman, Mark H.; Ognyanov, Vassil I.; Xi, Ning; US2006/84640; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128019-59-0,4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

61 (B) 4-Methyl-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester The crude piperazine-1, 3-dicarboxylic acid-1-tert-butyl ester (4.92 mmol), prepared as described in 62 (A), was suspended in dry acetonitrile (30 mL) under nitrogen atmosphere and formaldehyde (37% wt. aqueous solution, 367 mL, 4.92 mmol) and Na (OAc) 3BH (2.3 g, 10. 82 mmol) were added. The resulting mixture was stirred at R. T. for 3h, then a saturated aqueous solution of NaHC03 was slowly added until the pH was adjusted to 7. The mixture was concentrated to dryness under reduced pressure to give a yellow solid that was used without further purification for the next step. LCMS (Tr): 3.19 min (Method B); MS (ES+) gave m/z : 245.0., 128019-59-0

As the paragraph descriping shows that 128019-59-0 is playing an increasingly important role.

Reference£º
Patent; ADDEX PHARMACEUTICALS SA; WO2005/44797; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics