Month: May 2021

5753-26-4,5753-26-4, 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) A mixture of 8.5 g of 9-acridanone, 180 ml of dimethylformamide and 3.3 g of sodium hydride is stirred for 0.5 hour, treated portionwise with 10.3 g of 2-[1-(4-methyl)-piperazinyl]ethyl chloride dihydrochloride, stirred at 80 for 3 days and evaporated. The residue is treated with water and extracted with methylene chloride. The extract is washed with water, dried over sodium sulfate and evaporated, whereupon the residue is recrystallized firstly from ether and then from ethyl acetate. There is obtained 10-[2-(4-methyl-1-piperazinyl)ethyl]-9-acridanone of melting point 156-157.

As the paragraph descriping shows that 5753-26-4 is playing an increasingly important role.

Reference£º
Patent; Hoffman-La Roche Inc.; US4711889; (1987); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879896-50-1,2-(4-Methylpiperazin-1-ylmethyl)benzylamine,as a common compound, the synthetic route is as follows.,879896-50-1

Example 111 lambda/-Methoxy-4-methyl-3-[3-[[[2-[(4-methyl-1-piperazinyl)methyl]phenyl]methyl]amino]- 2-oxo-1(2H)-pyrazinyl]-benzamideTo a stirred solution of 3-(3,5-dibromo-2-oxo-2H-pyrazin-1-yl)-4-methyl-benzoic acid, methyl ester (Example 1 b, 0.1 g) in tetrahydrofuran (2 ml.) in a microwave vial was added triethylamine (250 mul_) and 2-[(4-methyl-1-piperazinyl)methyl]-benzenemethanamine (90 mg). The reaction was stirred overnight before the addition of O-methylhydroxylamine hydrochloride (83 mg) and cyclopentylmagnesium bromide (2M in diethyl ether, 2 ml.) dropwise. After stirring for 60 minutes, ethanol (2 ml.) was added followed by the addition of ammonium formate (0.4 g) and 10% palladium on carbon (40 mg). The reaction mixture was heated within a microwave for 30 minutes at 100C before being cooled to room temperature, filtered and washed with ethanol. The filtrate was concentrated in vacuo. Purification by preparative HPLC (Gemini column, 0.1 % trifluroacetic acid: acetonitrile eluent) afforded the title compound (13 mg). MS: APCI(+ve) 477 (M+H+).1H NMR delta(DMSO-d6, 400MHz) 7.77 (1 H, d), 7.67 (1 H, s), 7.51 (1 H, d), 7.41 (1 H, d), 7.33 – 7.27 (3H, m), 6.90 (1 H, d), 6.75 (1 H, d), 4.72 (1 H, d), 4.62 (1 H, d), 3.80 – 3.69 (2H, m), 3.69 (3H, s), 3.44 – 3.25 (4H, m), 2.70 (3H, s), 2.50 – 2.35 (2H, m), 2.12 (3H, s).

The synthetic route of 879896-50-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/1132; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1589082-06-3, (S)-tert-Butyl 3-(cyanomethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A reaction mixture of fert-butyl (3,51-3- (cyanomethyl)piperazine-l-carboxylate (850 mg, 3.77 mmol) and HCl/dioxane (4 M, 20 mL) was stirred at 15 C for 1 hour. Upon completion, the solvent was removed under vacuum to give 2-[(25)-piperazin-2-yl]acetonitrile (740 mg, 3.74 mmol, 99.0% yield, 2HC1) as a white solid. NMR (400MHz, METHANOLS) delta = 4.04 – 3.90 (m, 1H), 3.81 – 3.70 (m, 2H), 3.69 – 3.61 (m, 2H), 3.53 – 3.36 (m, 2H), 3.13 (d, J=6.4 Hz, 2H)., 1589082-06-3

As the paragraph descriping shows that 1589082-06-3 is playing an increasingly important role.

Reference£º
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143673-66-9,(R)-3-Isopropylpiperazine-2,5-dione,as a common compound, the synthetic route is as follows.

Step A: Preparation of (R)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine (1): To a 2 L round-bottomed flask were added (R)-3-isopropylpiperazine-2,5-dione (20.7 g, 133 mmol), Me3OBF4 (49.0 g, 331 mmol) and CH2Cl2 (500 mL). The slurry was stirred vigorously at room temperature under nitrogen atmosphere. After stirring 18 hours, the slurry became a clear solution with very viscous yellow oil settling on the bottom of the flask. An additional equivalent of Me3OBF4 (19.6 g, 133 mmol) was added and the mixture was stirred at room temperature. After 23 hours, the mixture was cooled in an ice bath, and 200 g of ice and 100 mL of concentrated ammonium hydroxide solution (28%) were added to the reaction mixture. The reaction mixture was stirred in an ice bath for 1 hour. The layers were separated and aqueous layer was extracted with CH2Cl2 (2*50 mL). The combined organic layers were washed with saturated NaHCO3 solution (2*100 mL) and brine (100 mL), dried over K2CO3, filtered through a Celite pad, and concentrated under reduced pressure to provide 25.9 g of light brown oil. The crude material was purified by chromatography with 1:4 ether/pentane to provide 17.464 g of compound 1 as a colorless oil (71.5% yield). 1H NMR (400 MHz, CDCl3) delta 4.08-3.94 (m, 3H), 2.95 (s, 3H), 2.87 (s, 3H), 2.30-2.18 (m, 1H), 1.04 (d, J=7.03 Hz, 3H), 0.76 (d, J=6.64 Hz, 3H).

143673-66-9, 143673-66-9 (R)-3-Isopropylpiperazine-2,5-dione 736000, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ARRAY BIOPHARMA INC.; US2006/264431; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1217599-13-7,(R)-1-Boc-2-Isobutylpiperazine,as a common compound, the synthetic route is as follows.

(R)-tert-but l 4-(6-chloro-5-cyano-3-fluoropyridin-2-yl)-2-isobutylpiperazine-l-carboxylateA mixture of tert-butyl (2R)-2-isobutylpiperazine-l-carboxylate (515 mg, 2.13 mmol), 2,6- dichloro-5-fluoro-pyridine-3-carbonitrile (405.9 mg, 2.13 mmol) and DIPEA (274.6 mg, 370.1 mu, 2.13 mmol) in NMP was heated at 130 C for 20 minutes under microwave conditions. After this time, the reaction mixture was allowed to cool to ambient temperature and diluted with EtOAc and water. The organic layer was separated and washed with brine, dried ( a2S04), filtered and concentrated in vacuo. The crude mixture was purified by column chromatography (ISCO Companion, 120 g column, eluting with EtO Ac/Petroleum ether) to give the sub title compound (629.9 mg, 75% Yield). XH NMR (400 MHz, CDC13) delta 7.37 (d, J= 12.6 Hz, 1H), 4.55 – 4.23 (m, 3H), 4.1 1 (q, J= 7.2 Hz, 1H), 3.23 (dd, J= 13.4, 3.6 Hz, 1H), 3.08 (d, J= 9.4 Hz, 2H), 1.64 – 1.52 (m, 1H), 1.50 – 1.28 (m, 1 1H), 0.93 (d, J= 6.5 Hz, 6H).

1217599-13-7, As the paragraph descriping shows that 1217599-13-7 is playing an increasingly important role.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; JIMENEZ, Juan-Miguel; GOLEC, Julian, M.C.; SETTIMO, Luca; FRAYSSE, Damien; BRENCHLEY, Guy; BOYALL, Dean; TWIN, Heather; YOUNG, Stephen; MILLER, Andrew, W.; DAVIS, Christopher, John; WO2011/94283; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

128019-59-0, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 10; Piperazine-1, 2,4-tricarboxylic acid 4-tert-butyl ester 1- (9H-fluoren-9-ylmethyl) ester; A solution of 9-fluorenylmethyl chloroformate (2.72 g, 10.5 mmol) in 1,4-dioxane (19 mL) was added drop-wise to a solution of piperazine-1, 3-dicarboxylic acid 1-tert-butyl ester (2.20 g, 9.6 mmol) and N, N-diisopropylethylamine (4.2 mL, 23.9 mmol) in water (9.5 mL) in an ice-bath. After stirring overnight at room temperature, the reaction mixture was diluted with water and extracted with chloroform (4 times). The organic layer was washed with saturated sodium bicarbonate and water and then 1N HCl and water, dried over anhydrous sodium sulfate, filtered, and concentrated to afford piperazine-1,2, 4- tricarboxylic acid 4-tert-butyl ester 1- (9H-fluoren-9-ylmethyl) ester (4.3g)., 128019-59-0

The synthetic route of 128019-59-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2005/80386; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84477-72-5,2,2-Dimethylpiperazine,as a common compound, the synthetic route is as follows.,84477-72-5

To a solution of 2,2-dimethylpiperazine (400 mg) in dichloromethane (20 mL) at 0 C. was added di-tert-butyl dicarbonate (766 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL) and extracted into dichloromethane (2*40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4) and concentrated to give 3,3-diemethyl-piperazine-1-carboxylic acid tert-butyl ester as a white solid (720 mg, 96%).

The synthetic route of 84477-72-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Piramed Limited; Genentech, Inc.; US2008/76758; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1589082-06-3,(S)-tert-Butyl 3-(cyanomethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A reaction mixture of tert-butyl (3S)-3-(cyanomethyl)piperazine-1-carboxylate (850 mg, 3.77 mmol) and HCl/dioxane (4 M, 20 mL) was stirred at 15¡ã C. for 1 hour. Upon completion, the solvent was removed under vacuum to give 2-[(2S)-piperazin-2-yl]acetonitrile (740 mg, 3.74 mmol, 99.0% yield, 2HCl) as a white solid. 1H NMR (400 MHz, METHANOL-d 4) delta=4.04-3.90 (m, 1H), 3.81-3.70 (m, 2H), 3.69-3.61 (m, 2H), 3.53-3.36 (m, 2H), 3.13 (d, J=6.4 Hz, 2H)., 1589082-06-3

The synthetic route of 1589082-06-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mirati Therapeutics, Inc.; Array BioPharma Inc.; Blake, James F.; Burgess, Laurence E.; Chicarelli, Mark Joseph; Christensen, James Gail; Cook, Adam; Fell, Jay Bradford; Fischer, John P.; Marx, Matthew Arnold; Mejia, Macedonio J.; Savechenkov, Pavel; Vigers, Guy P.A.; Smith, Christopher Ronald; Rodriguez, Martha E.; US2019/144444; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

84477-72-5, 2,2-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

84477-72-5, [Referential Example 280] 1-(tert-Butoxycarbonyl)-3,3-dimethylpiperazine To a methylene chloride solution (5.0 ml) of 2,2-dimethylpiperazine (460 mg, 4.03 mmol) (J. Med. Chem., 1995, 38, 4389) was added di-tert-butyl dicarbonate (780 mul). The resulting mixture was stirred for 3 hours. The reaction mixture was diluted with methylene chloride and then added with saturated aqueous NaCl solution to separate into two layers. The water layer thus obtained was extracted with methylene chloride. The extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crudely purified product was purified by chromatography on a silica gel column (methylene chloride: methanol = 10:1), whereby the title compound (360 mg) was obtained as a colorless oil. 1H-NMR (CDCl3) delta: 1.19(6H,s), 1.46(9H,s), 2.93(2H,t,J=4.9Hz), 3.23(2H,s), 3.42-3.48(2H,br), 3.95-4.01(1H,s).

84477-72-5 2,2-Dimethylpiperazine 14664186, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1104754; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5753-26-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5753-26-4,1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride,as a common compound, the synthetic route is as follows.

[4-CYCLOPENTYLAMINO-6-HYDROXY-QUINAZOLINE-2-CARBONITRILE] (0. [4MMOL),] 1- (2-Chloro- ethyl) -4-methyl-piperazine dihydrochloride [(0.] [55MMOL)] and cesium carbonate [(4MMOL)] are stirred in DMF [(5ML)] at RT for 20 hours. The suspension is filtered, washed with little DMF and water is added to the filtrate until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 110- [112C,] [RIF0.] 48 [(CH2CL2/MEOH=9] : 2) is obtained. [‘H-NMR] [(CDC13)] : 1.5-1. 9 [(M,] 6H), 2.2 [(M,] 2H), 2.35 (s, 3H), 2.4-2. 75 [(M,] 8H), 2.9 [(M,] [2H),] 4.25 [(M,] 2H), 4.6 [(M,] 1H), 6.85 (broad d, 1H), 7.05 (d, 1H), 7.45 (dd, 1H), 7.8 (d, [1H).]

5753-26-4 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride 11183940, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/20441; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics