Month: May 2021

630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

630125-91-6, 4-((4-ethylpiperazin-l-yl)methyl)-3-(trifluoromethyl)benzeneamine (30.6 mg) in 1,4-dioxane (1 mNo.), was added 4-nitrophenylchloroformate (21.6 mg) at room temperature. After 60 0C at 1 h, them mixture was cooled to rt and ethyl 6-(3-aminophenyl)-lH-indazole-3-carboxylate (30 mg) was added. The mixture was stirred at 90 0Cf or 12 h. Ethyl acetate and water were added and the aqueous layer was extracted with ethyl acetate three times. The combined organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was triturated in ethyl acetate/hexane to give6-(3-(3-(4-((4-ethylpiperazin-l-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenyl)-l H-indazole-3-carboxylate (16.2 mg).[643] [644] 1H NMR (400 MHz, DMSOd6) 613.98 (s, IH), 9.09 (s, IH), 8.93 (s, IH), 8.15 (8.4 Hz, IH), 7.99 (s, IH), 7.93 (s, IH), 7.81 (s, IH), 7.62 (m, 3H), 7.43 (br d, J = 4.4 Hz, 2H), 7.28 (m, IH), 4.41 (q, J = 7.2 Hz, 2H), 3.54 (s, 2H), 2.49 (m, 10H), 1.39 (t, J = 7.2 Hz, 3H).

As the paragraph descriping shows that 630125-91-6 is playing an increasingly important role.

Reference£º
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; SIM, Tae Bo; SON, Jung Beom; KIM, Hwan; PARK, Dong Sik; CHOI, Hwan Geun; HAM, Young Jin; HAH, Jung Mi; YOO, Kyung Ho; OH, Chang Hyun; LEE, So Ha; HA, Jae Du; CHO, Sung Yun; KWON, Byoung-Mog; HAN, Dong Cho; WO2010/64875; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50606-32-1,Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,50606-32-1

Example 11: (lalpha,5alpha,6beta)-3-{6-[(S)-l-(4-Butoxycarbonyl-piperazine-l-carbonyl)-2- methyl-propylcarbamoyll^-phenyl-pyrimidin^-ylJ-S-aza-bicyclop.l.Olhexane– carboxylic acid:11.1. 4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-piperazine-l-carboxylic acid butyl ester:To a solution of Boc-(L)-Val-OH (400 mg) in DCM (12 mL) were added DIPEA (0.991 mL), DMAP (22 mg), HOBT hydrate (298 mg), EDCI hydrochloride (423 mg) and intermediate 1.4 (343 mg). The mixture was stirred at RT for 6 h. An aq. NaHCO3 solution was added to the mixture and the phases were separated. The org. phase was washed with brine, dried (MgStheta4) and evaporated off to afford 844 mg of the desired compound as beige oil. LC-MS: tR = 1.02 min; [M+H]+: 386.42.

The synthetic route of 50606-32-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; MEYER, Emmanuel; RENNEBERG, Dorte; WO2010/116328; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154590-35-9,tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Step 1: Cool in ice a solution of glycidol (0.63 g, 8.5 mmol) in ether (30 ml). Add DIPEA (1.6 ml, 8.5 mmol) and phosgene (1.85M in toluene, 5.8 ml, 10.8 mmol). Stir 2 h, filter, and concentrate. Dissolve in ether (50 ml) and add the product of Preparation 13, Step 3 (2.50 g, 7.7 mmol) and DIPEA (1.6 ml, 8.5 mmol). Stir 2 h, wash with sat. NaHCO3, dry (MgSO4), and concentrate to obtain the carbamate as a yellow solid

154590-35-9, The synthetic route of 154590-35-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schering Corporation; US2004/220194; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.955400-16-5,(S)-tert-Butyl 3-(methoxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,955400-16-5

A mixture of tert-butyl (3S)-3-(methoxymethyl)piperazine-1-carboxylate (633 mg), ethyl acrylate (0.39 mL), and ethanol (1.9 mL) was stirred at 80C for 3 hours under microwave irradiation. The reaction mixture was cooled to room temperature, and then was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain tert-butyl (3S)-4-(3-ethoxy-3-oxopropyl)-3-(methoxymethyl)piperazine-1-carboxylate (444 mg) as an oil.

The synthetic route of 955400-16-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Astellas Pharma Inc.; TAKAHASHI, Taisuke; TANAKA, Hiroaki; AKAIWA, Michinori; NEGORO, Kenji; MIHARA, Hisashi; FUJI, Hideyoshi; TAKAMATSU, Hajime; (133 pag.)EP3196200; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1:The mixture of methyl (¡À)-4-Boc-piperazine-2-carboxylate (CAS: 129799-08-2, 2.44 g, 0.01 mol), TEA (1.52 g, 0.015 mol) in DCM (10 mL) was added to a solution of (4-nitrophenyl) carbonochloridate (2.42 g, 0.012 mol) in DCM (10 mL). After 1 hour at rt, the organic layer was washed with water and saturated sodium bicarbonate solution, dried over sodium sulfate. After removal of solvent, the crude product 67-B was obtained and used in the next step without purification. MS: calc’d 410 (MH+), measured 410 (MH+)., 129799-08-2

As the paragraph descriping shows that 129799-08-2 is playing an increasingly important role.

Reference£º
Patent; HOFFMANN-LA ROCHE INC.; Guo, Lei; Hu, Taishan; Kou, Buyu; Lin, Xianfeng; Shen, Hong; Shi, Houguang; Yan, Shixiang; Zhang, Weixing; Zhang, Zhisen; Zhou, Mingwei; Zhu, Wei; US2015/252057; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 1-(2-hydroxyethyl)-4-methylpiperazine used as a stating material was prepared as follows: [00711] A mixture of 2-bromoethanol (2.36 g), N-methylpiperzine (1.26 g), potassium carbonate (5.0 g) and ethanol (150 ml) was stirred and heated to reflux for 1.8 hours. The mixture was cooled to ambient temperature and filtered. The filtrate was evaporated and the residue was triturated under a mixture of methylene chloride and acetone. The resultant mixture was filtered and the filtrate was evaporated to give the required starting material as an oil (0.87 g); NMR Spectrum: (CDCl3) 2.18 (s, 3H), 2.3-2.7 (br m, 8H), 2.56 (t, 2H), 3.61 (t, 2H)., 109-01-3

The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AstraZeneca UK Limited; US6806274; (2004); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 24A 3-methyl-1-pyridin-2-ylpiperazine hydrobromide 2-Methylpiperazine (1.0 g, 0.01 mol, racemic mixture) and 2-bromopyridine (10 mL, 0.1 mol) were combined and heated at 120 C. for 16 hours. The reaction mixture was cooled to 23 C. and partitioned between ethyl acetate and water. The layers were separated, and the water layer was concentrated under reduced pressure. The residue was triturated with ethyl acetate, dichloromethane, and methanol to afford 460 mg (26% yield) of the title compound as an off-white solid. 1H NMR (300 MHz, DMSO-d6) delta1.27 (d, J=6.6 Hz, 3H), 2.90 (dd, J=10.5, 14.1 Hz, 1H), 3.10 (m, 2H), 3.40 (m, 2H), 4.32 (m, 2H), 6.77 (dd, J=4.8, 6.9 Hz, 1H), 6.98 (d, J=8.1 Hz, 1H), 7.64 (m, 1H), 8.15 (m, 1H), 8.63 (bs, 1H), 8.92 (bs, 1H); MS (APCI) m/e 178 (M+H)+., 109-07-9

As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.

Reference£º
Patent; Cowart, Marlon D.; Bhatia, Pramila A.; Daanen, Jerome F.; Stewart, Andrew O.; Patel, Meena V.; Kolasa, Teodozyj; Brioni, Jorge D.; Rohde, Jeffrey; Engstrom, Kenneth M.; US2003/162790; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Z-rnethoxy4–(4-rnethyipiperazin- 1 -yl)aniline (10 g, 452 nunol) in toluene (230 mL) was added Di-tert-butyi dicarbonate (9.87 g, 45.2 mmol). The reaction mixture was stirred at 120 C for 6 hrs and concentrated under reduced pressure. The residue was purified by cohmm chromatography on silica gel (3:97 to 10:90, ammonia solution 7.0 N in methaiiolIdichioromethane) to afford title compound (12.5 g, 86% yield). Rt = 3.23 mm;?H NMR 600 MHz (DMSO-d6) d 7.62 (s, IH), 7.31 (/nc IH), 6.52 (d, .J 2.4 Hz, 1H), 6.38 (dci, J= 2.4 Hz, J= L0 Hz, 1H), 3.72 (s, 3H), 3.04 (in, 4H), 2.39 (in, 4H), 2.17 (s, 3H), 1.38 (r, 9H); MS ni/z: 321.99 [M+ii,., 122833-04-9

122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael; CHOI, Hwan Geun; TAN, Li; WO2015/6492; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

113028-17-4, Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

the reaction vessel 8. 0kg a compound of formula (II), 112kg water, 6. 0kg potassium hydroxide, and heated to 60~ 70 C the hydrolysis reaction, 2 to 3 hours. After completion of the reaction, was cooled to room temperature, 30. 4kg washed with ethyl acetate, the aqueous layer was separated, stirred, adjusted with concentrated hydrochloric acid rhoEta 6~7, stirring was continued for 0.5 hours, the filter cake was suction filtration, an appropriate amount of ethyl washing the filter cake drying, cake was collected, 60~70 C hot air circulation drying, to obtain a compound of formula (III) finished 7. 36kg, yield (mol) 96.4%, purity 97.3%;, 113028-17-4

113028-17-4 Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 10249018, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Jumpcan Pharmaceutical Group/ji chuan(jiang su)Jumpcan Pharmaceutical Group co.ltd; cao, Longxiang; dong, Zibo; niu, ben; shao, Jianguo; (12 pag.)CN103113392; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6531-38-0,2,2′-(Piperazine-1,4-diyl)diethanamine,as a common compound, the synthetic route is as follows.

Example 34 (compound No.13; *) l,4-bis{2-[4-chlorobenzyl)amino]ethyl}piperazine; To a solution of l,4-bis(2-aminoethyl)piperazine (0.43g, 2.5 mmol) and 4- chlorobenzaldehyde (737 mg, 5.24 mmol) in absolute ethanol (20 mL), 3 A molecular sieves are added. After stirring the mixture at room temperature for 12h, NaBH4 (1.9 g, 49.92 mmol) was added portionwise and the mixture was stirred for 12h at room temperature. The reaction was quentched by dropwise addition of water (20 mL) and ethanol was removed under reduced pressure. The aqueous residue was extracted with EPO CH2Cl2 (3 x 30 mL). Combined organic layers were extracted with HCl IM. The combined aqueous layers were neutralized with NaOH IM and extracted with CH2Cl2. Combined organic layers were dried over MgSO4. Crude compound is purified by thick-layer chromatography (CH2Cl2/Me0H : 80/20).

6531-38-0, As the paragraph descriping shows that 6531-38-0 is playing an increasingly important role.

Reference£º
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DU DROIT ET DE LA SANTE – LILLE II; WO2006/51489; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics