Month: May 2021

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

934-98-5, To a solution of?(S)-7?(2.00 g, 7.0 mmol) in DCM (60 mL), DEPBT (2.01 g, 7.0 mmol) and DIPEA (2.44 mL, 14.0 mmol) were added and reaction mixture was stirred at room temperature for 5 min. 2-(4-Methyl-piperazin-1-yl)ethylamine?8b?(1.00 g, 7.0 mmol) was added to the reaction mixture and it was stirred at room temperature for 18 H. Mixture was quenched with H2O (60 mL) and organic layer was washed with brine (2×60 mL), dried over Na2SO4?filtered and evaporated. The residue was purified by flash column chromatography eluting with?DCM : MeOH (95 : 5) to afford 1.91 g of the titled compound?9b?as a white solid (66 percent):?mp 154-155 °C;??[alpha]D20+ 49.7 (c?1, MeOH);?deltaH?(400 MHz; CDCl3) 7.34-7.24 (10H, m), 6.27-6.25 (2H, m), 5.15-4.97 (3H, m), 3.24 (2H, q,?J?= 5.5 Hz), 2.40-2.29 (10H, m), 2.21 (3H, s);?13C NMR (300 MHz; CDCl3) 170.3, 139.4, 137.1, 129.9, 129.3, 129.2, 129.0, 128.9, 128.0, 67.8, 59.7, 56.5, 55.8, 53.4, 46.9, 37.0;?HR-MS [M + H]+?observed = 411.2410, calculated = 411.2391.

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Article; Hanessian, Stephen; Babonneau, Vincent; Boyer, Nicolas; Mannoury La Cour, Clotilde; Millan, Mark J.; De Nanteuil, Guillaume; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 510 – 514;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of oxirane (0.17mmol) in methanol (5 mL) was added the appropriate secondary amines (0.17mmol).Then the reaction mixture was refluxed for 24 h. After completion, the reaction mixture was allowed to room temperature the resulting crude was concentrated under reduced pressure and purified by column chromatography to yield the corresponding beta-amino alcohol derivatives., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Article; Vanguru, Sowmya; Jilla, Lavanya; Sajja, Yasodakrishna; Bantu, Rajashaker; Nagarapu, Lingaiah; Nanubolu, Jagadeesh Babu; Bhaskar, Bala; Jain, Nishant; Sivan, Sreekanth; Manga, Vijjulatha; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 792 – 796;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

mixture of 6-chloro-pyrimidin-4-yl)-amine (500 mg, 3.87 mmol, 1.3 eq.) and 4-(4-ethylpiperazin-1-yl)-aniline (611 mg, 2.98 mmol) in water (3.0 ml) and glacial acetic acid (10ml) is heated to 100C for 15h. The reaction mixture is diluted with DCM and brine. Theaqueous layer is made basic by addition of sodium bicarbonate. The aqueous layer isseparated and extracted with DCM. The organic phase is washed with brine, dried (sodiumsulfate), filtered and concentrated. Purification of the crude product by trituration in EEaffords the title compound: ESI-MS: 299.2 [MHf; tR= 1.05 min (gradient J).

115619-01-7, As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.

Reference：
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; IRM LLC; WO2006/420; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5271-27-2

General procedure: A mixture of 1a-c (1.93 g, 10 mmol), 4 (1.76 g, 10mmol) and KF (18 mmol) were heated at 120-130 °C inDMF (30 mL) for 16 – 18 h. At the end of this period, thereaction mixture was cooled to room temperature and dilutedwith water (30 mL). The separated solid was filtered, washedand dried to obtain crude 5a-i. The obtained crude productwas then purified by recrystallization using ethanol

5271-27-2 1-Methyl-3-phenylpiperazine 2760009, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Darsi, S.S. Praveen Kumar; Kumar, K. Shiva; Devi, B. Rama; Naidu; Dubey; Letters in Organic Chemistry; vol. 11; 8; (2014); p. 551 – 555;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5271-27-2,5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The solution of compound 1 (150 mg, 0.64 mmol), 1-Methyl-3-phenylpiperazine (112 mg, 0.64 mmol), NaI (190 mg, 1.27 mmol) and DIPEA (0.22 ml, 1.27 mmol) DMSO (3.5 mL) was stirred at 135° C. for 48 h with oil bath. TLC was used to monitor the reaction. After cooled to room temperature, the reaction mixture was added to half-saturated ammonium chloride in water (80 mL) and stirred for 30 min. The solids were collected by filtration, washed by water. The crude product was purified by column chromatography (0-10percent MeOH in DCM) to give compound 65 as yellow solids. (51 mg, 21percent yield). 1H NMR (400 MHz, DMSO-d6) delta 11.91 (s, 1H), 9.12 (s, 1H), 8.08 (s, 1H), 7.30-7.00 (m, 5H), 6.70 (b, 1H), 5.75 (b, 1H), 5.54 (br, 1H), 4.02 (br, 1H), 3.32 (m, 1H), 3.12 (m, 1H), 2.80 (m, 1H), 2.32 (m, 1H), 2.16 (s, 3H), 1.98 (m, 1H), 1.82 (m, 1H), 0.88 (m, 2H), 0.62 (m, 2H); ESI-MS: calcd for (C21H25N7) 375, found 376 (MH+).

As the paragraph descriping shows that 5271-27-2 is playing an increasingly important role.

Reference：
Patent; NantBio, Inc.; Tao, Chunlin; Wang, Qinwei; Asad, Sharif; Weingarten, Paul; Ci, Sherry; US2018/346451; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

General procedure: To a stirring solution of compound 8 (200mg, 0.35mmol) in DCM (10mL) was added EDCI (91mg, 0.47mmol), HOBt (64mg, 0.47mmol) and the corresponding diamine derivatives (0.35mmol) with a drop of DIPEA. The reaction mixture was stirred for 12hat room temperature, then washed with diluted HCl and saturated brines. The organic layer were combined and dried over anhydrous Na2SO4, concentrated in vacuo, and then purified by flash chromatography to give product 9b-9h, 9k-9x, respectively.

934-98-5, As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Article; Xu, Xiao-li; Yang, Ying-rui; Mo, Xiao-fei; Wei, Jin-lian; Zhang, Xiao-jin; You, Qi-dong; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 45 – 62;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5625-67-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.

iii 3-Oxo-piperazine-1-carboxylic Acid Tert-Butyl Ester Oxopiperazine (3.38 g, 34 mmol) is dissolved in 20 mL of CH2Cl2. Et3N (9.5 mL, 68 mmol) is added followed by Boc2O (7.4 g, 34 mmol). The solution is allowed to stir at ambient temperature for 3 hours, at which time the reaction is quenched by the addition of brine. The phases are separated and the organic phase is washed with brine, 1 M aqueous KH2PO4 and dried over Na2SO4. The mixture is filtered and concentrated to give iii as a white solid (6.1 g, 30 mmol, 90%). (MS: M+H: 199.0).

5625-67-2 Piperazin-2-one 231360, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Gailunas, Andrea; Tucker, John A.; TenBrink, Ruth; Mickelson, John; US2003/109559; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 2-chloro-4-(trifluoromethyl)-benzonitrile (1.00 mmol), appropriate amine (NR2, 2.00 mmol),and DBU (2.5 mmol) were dissolved in 1,4-dioxane (8 ml). Themixture was stirred for 12 h at 50 C. The reaction was quenched with water and extracted with EtOAc twice. The combined organicextracts were dried over MgSO4, filtered, and concentrated invacuo. The residue was purified by flash column chromatographyon silica gel using EtOAc/hexane (1:7-1:10) eluant condition.(NR2 = 4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloridefor 17).

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Ann, Jihyae; Jung, Aeran; Kim, Mi-Yeon; Kim, Hyuk-Min; Ryu, Hyungchul; Kim, Sunjoo; Kang, Dong Wook; Hong, Sunhye; Cui, Minghua; Choi, Sun; Blumberg, Peter M.; Frank-Foltyn, Robert; Bahrenberg, Gregor; Stockhausen, Hannelore; Christoph, Thomas; Lee, Jeewoo; Bioorganic and Medicinal Chemistry; vol. 23; 21; (2015); p. 6844 – 6854;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27469-60-9,4,4-Difluorobenzhydrylpiperazine,as a common compound, the synthetic route is as follows.

Example 27 : Preparation of2-(2-(4-(bis(4-fluorophenyl)methyl)piperazin-l-yl)-2-oxoethylamino)-N-(4-phenyl butan-2-yl)acetamide; [371] [372] 0.5 mmol of N-((t-butyloxy)carbonyl)-N’-(l-methyl-3-phenylpropyl)iminodiacetic acid monoamide, 0.55 mmol of l-(bis(4-fluorophenyl)methyl)piperazine, and PyBOP were added to 3 mL of DMF to dissolve. Then, 1.0 mmol ofN,N-diisopropylethylamine (DIEA) was added thereto, and stirred at room temperature for 16 hours. 20 mL of 10% HCl was put into the reaction solution, and extracted with 30 mL of EtOAc. The organic layer was washed with 20 mL of 10% HCl, and then washed with 20 mL of a saturated NaHCO solution twice and with 20 mL of a saturated NaCl solution twice. The organic layer was collected, dried over anhydrous MgSO , and filtered under reduced pressure. The organic solvent in the filtrate was removed under reduced pressure. The residue was purified by column chromatography with a mixed solvent of EtOAc and methanol (20: 1), so as to obtain N- ((t-butyloxy)carbonyl)-N’-(l-methyl-3-phenylpropyl)-N”-l-(bis(4-fluorophenyl)methyl )piperazine iminodiacetic acid diamide. Chloroform (1 mL) and 4 M HCl-dioxane (1 mL) were added to the obtained compound, and left to stand for 3 hours. The solvent was removed under reduced pressure, so as to obtain the title compound (white solid, yield: 56%).[373] mp 148-1520C;[374] 1U NMR (CDCl 400MHz) delta 1.147(d, 3H, J=6.4Hz), 1.605-1.846(m, 2H),2.575-2.716(m, 2H), 3.163~3.431(m, 4H), 3.776~3.994(m, 4H), 4.052~4.214(m, 2H), 4.326~4.499(m, 2H), 5.486(br s, IH), 6.010(s, IH), 7.046- 7.247 (m, 8H), 8.173(br s, 4H), 8.520~8.650(m, IH);[375] FABHRMS (m/z):535.2885 (M++., requires C 31 H 37 N 4O 2F 2: 535.2806).

27469-60-9, The synthetic route of 27469-60-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; PARK CHOO, Hea-Young; WO2007/142431; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of carboxylic acid (50 mmol) in DMF (0.25 mL) in a 48 position Mettler Toledo XT reaction block was added PyBOP (50 mmol, 0.2 mL of 0.3 M solution in DMF) and TEA (75 mmol, 0.05 mL of 1.5 M solution in DMF) followed by the appropriate amine build blocks (55 mmol, 0.55 ml of 1 M solution in DMF). The reactions were stirred at rt 24 h and concentrated by GeneVac HT-4 to remove all reaction mixture including excess amine and DMF. The crude mixtures were dissolved in EtOAc (1 mL) and filtered through silica-packed short-column and washed with EtOAc (3 mL). The collected organic solution was concentrated in GeneVac HT-4 and dissolved in DMSO (1 mL). DMSO solution was subjected to HTAC for pre-purification analysis, purification, and final QC., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Hwang, Jong Yeon; Attia, Ramy R.; Carrillo, Angela K.; Connelly, Michele C.; Guy, R. Kiplin; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1891 – 1895;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics