With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Step C: tert-butyl (38)-4-[2-(2, 1 ,3-benzoxadiazol-5-yl)-2-hydroxyethyll -3-(hydroxymethyl)piperazine-1-carboxylate: To a microwave tube containing a stir bar was added5-(oxiran-2-yl)-2,1,3-benzoxadiazole (1.2 g, 7.4 mmol), Boc-piperizine alcohol (2.8 g, 13.3mmol); the resulting mixture was dissolved in anhydrous toluene (15 mL), purged with N2 andthe tube was heated in a microwave reactor for 1 h at 150 C. TLC analysis of the rectrion mix.showed the completion of the reaction. The solution was concentrated to dryness and absorbed into silica gel and was subjected for purification over a silica column to give the title compound., 314741-40-7
The synthetic route of 314741-40-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DEJESUS, Reynalda, Keh; FRIE, Jessica, L.; PIO, Barbara; TANG, Haifeng; WALSH, Shawn, P.; WO2014/99633; (2014); A2;,
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