122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 2-methoxy-4-(4-methylpiperazin-l-yl)aniline (331 mg, 1.5 mmol, 1 eq.) and 8-bromo-2-chloroquinazoline (363 mg, 1.5 mmol, 1 eq.) in n-BuOH (10 mL) was added TFA (0.14 mL, 1.8 mmol, 1.2 eq.). The mixture was stirred at 110 C for 12 h. The solution was then cooled to r.t. and concentrated. The resulting residue was dissolved in EA (20 mL), washed with aqueous Na2C03 solution, dried over anhydrous Na2S04and concentrated. The resulting residue was purified via column chromatography (EA/MeOH=5 : 1 , v/v) to afford 8-bromo-N-(2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)quinazolin-2-amine (140 mg, 22% yield)., 122833-04-9
The synthetic route of 122833-04-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-Liang; WO2015/27222; (2015); A2;,
Piperazine – Wikipedia
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