With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129799-08-2,1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.,129799-08-2
To a solution of I-a?ert-butyl 3-methyl piperazine-1,3-dicarboxylate (10.0 g, 70 mmol) in THF(200 mL) was added triethyl amine and benzyl bromide. The mixture was then stined at roomtemperature for 12 hours and concentrated in vacuo. The residue was then diluted with ethylacetate and water. The aqueous layer was discarded and the organic layer was washed once with water, dried over Na2SO4, filtered, and concentrated in vacuo. The residue was then purified by silica-gel chromatography (0 – 10 % MeOH in DCM) to afford the desired product.
The synthetic route of 129799-08-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; GEHLING, Victor; HSIAO-WEI TSUI, Vickie; KIEFER, James, Richard, Jr.; LIANG, Jun; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; ZHANG, Birong; (287 pag.)WO2016/112284; (2016); A1;,
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