With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.
To a solution of 1-(bromomethyl)-4-nitrobenzene (4.0 g, 18.5 mmol) and 1- methylpiperazine (1.7 g, 17.0 mmol) in CH3CN was added K2CO3 (3.8 g, 27.5 mmol), the mixture was stirred at 85 oC overnight. After completion, removed the solvent, extracted with ethyl acetate (150 mL × 3), washed with water (80 mL × 2), brine (80 mL × 2), dried with Na2SO4, purified by silica gel (DCM / MeOH = 50/1, 30/1), light brown solid 1-methyl-4-(4-nitrobenzyl)piperazine (3.3 g) was obtained, yield 76%. LC/MS (ESI) m/z = 236 (M + H) +.
109-01-3, The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; GRAY, Nathanael, S.; LIANG, Yanke; CHOI, Hwan, Geun; SUNDBERG, Thomas; SHAMJI, Alykhan; XAVIER, Ramnik; FISHER, David E.; (251 pag.)WO2018/9544; (2018); A1;,
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