With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.
The 5 mmol N, N – dimethyl glycine, 2 mmol CuI, 20 mmol 4, 6 – dichloro -2 – methyl pyrimidine dissolved in 100 ml DMF, under stirring, add 22 mmol N – hydroxyethyl piperazine, 40 mmol K3PO4, Stirring at room temperature for 40 min, added under mixing 2 – amino – N – (2 – chloro -6 – methyl phenyl) -5 – thiazole carboxamide 22 mmol. Through N2, For 120 C lower reaction 6 h after, adding 50 ml ammonia dissolved copper salt, for 50 ml × 3 ethyl acetate extraction, the combined acetic acid ethyl ester, saturated salt water for washing, the organic layer using anhydrous Na2SO4Drying, get the crude product. The crude product by adding 80% ethanol aqueous solution 100 ml, under stirring, by adding 2 g of activated carbon, reflux 30 min, is still hot filtration, filtrate refrigeration crystallization overnight, filtered, the filter cake of ice 80% ethanol aqueous solution washing, drying, to obtain white solid 8.64 g, yield 88.41% above, purity 99.92% above.
103-76-4, 103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Gao Hongjun; Lv Peng; Yang Jianzhu; (11 pag.)CN109369638; (2019); A;,
Piperazine – Wikipedia
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