Downstream synthetic route of 4318-42-7

4318-42-7, As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

Intermediate B65: 5-[4-(1 -methylethyl)-1 -piperazinyl]-2-(methyloxy)aniline; Step A/Intermediate B66: 1-(1-methylethyl)-4-[4-(methyloxy)-3- nitrophenyl]piperazine; To an N2 degassed solution of 1 ,4-dioxane (50 mL, Aldrich) was added 4-bromo-1- (methyloxy)-2-nitrobenzene (1.0 g, 4.31 mmol, Aldrich), XANTPHOS (0.74 g, 1.28 mmol, Aldrich), Pd2(dba)3 (0.79 g, 0.86 mmol, Aldrich), Cs2CO3 (2.8 g, 8.63 mmol, Aldrich), and 1-isopropylpiperazine (1.10 g, 8.6 mmol, Oakwood Chemicals). After heating overnight at 9O0C, the reaction was diluted with ethyl acetate (50 ml_), washed with water (50 ml_), organic layer adsorbed to silica gel and purified by column chromatography (dichloromethane to 5percent methanol/dichloromethane) to afford 1-(1-methylethyl)-4-[4-(methyloxy)-3-nitrophenyl]piperazine (0.66 g, 55percent). ESIMS (M+H)+ = 280.

4318-42-7, As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

Reference：
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/20990; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics