30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: The crude acid chloride 7 obtained in the previous step was cooledto 0 C and dissolved in dry DMF (2 mL). To this solution, the appropriateamine (1.65 mmol) and triethylamine (1 mL, 10 mmol) wereadded. The reaction mixture was stirred at 100 C for 6 h. The solutionwas poured over crushed ice and the precipitated solid was filtered off,washed with water, dried and recrystallized from the suitable solvent. Yield: 65%, m.p.: 120-122?C, I.R (KBr, cm-1): upsilonmax 3464 (NH), 3116 (CH aromatic), 2924 (CH aliphatic), 1670 (2C=O), 1635 (C=N), 1550 (C=C), 1H NMR: delta 3.35 (s, 8H, piperazinyl-H), 4.37 (s, 2H, CH2), 7.18-7.24 (m, 2H, trifluorophenyl-H), 7.37-7.45 (m, 6H, trifluorophenyl-H and phenyl-H), 7.87-7.90 (m, 1H, pyridyl-H), 8.40 (d, 1H, J?=?8.2?Hz, pyridyl-H), 9.05 (d, 1H, J?=?3.5?Hz, pyridyl-H), 12.86 (s, 1H, NH exchanged by D2O). Anal. Calcd. for C26H22F3N5O2 (493.49): C, 63.28; H, 4.49; N, 14.19. Found: C, 63.56; H, 4.65; N, 14.53.
30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Elmasry, Ghada F.; Aly, Enayat E.; Awadallah, Fadi M.; El-Moghazy, Samir M.; Bioorganic Chemistry; vol. 87; (2019); p. 655 – 666;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics