With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.697305-48-9,1-(4-Fluorophenyl)piperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.
A mixture of 3-chloro-6-(1 H-pyrazol-4-yl)-8-(trifluoromethyl)imidazo[1 ,2- a]pyridine-2-carboxylic acid (0.097 g, 0.295 mmol), 1-(4-fluorophenyl)-2-piperazinone hydrochloride (0.068 g, 0.295 mmol), DIPEA (0.154 mL, 0.884 mmol) and HATU (0.135 g, 0.354 mmol) in DMF (2 mL) was stirred at room temperature for one hour. The reaction mixture was diluted with EtOAc and washed with water and brine. The organic layer was dried over sodium sulfate and concentrated. The residue was purified by reverse phase HPLC (acetonitrile:water with 0.1 % formic acid) to give the title compound (0.045 g, 29%) as a white solid. 1H NMR (400 MHz, DMSO-c 6) delta ppm 13.19 (br. s., 1 H) 8.87 (s, 1 H) 8.59 (m, 1 H) 8.24 (m, 2 H) 7.33 – 7.61 (m, 2 H) 7.26 (t, 2 H) 4.69 (s, 1 H) 4.42 (m, 1 H) 4.13 – 4.29 (m, 1 H) 3.99 – 4.13 (m, 1 H) 3.81 (m, 2 H). ES-LCMS m/z: 507 (M+1 )., 697305-48-9
The synthetic route of 697305-48-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; PEAT, Andrew, James; PRICE, Daniel, J.; SHOTWELL, John, Brad; TAI, Vincent; ZHANG, Huichang; WO2011/41713; (2011); A2;,
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