120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example C.4 Preparation of rac-4-(6-Carboxy-pyridin-3-yl)-2-methyl-piperazine-1 carboxylic acid tertbutylester A solution of 5-fluoropicolinic acid (0.47g, 3.33 mmol) and 2-methylpiperazine N1 Boc (1.00 g,5.00 mmol) in DMA (2.00 ml) was heated to 160C in a microwave reactor for 1 hour. Thesolvent was evaporated under high vacuum. The residue was taken in water and acidified to pH 3.The aqueous phase was extracted 3 times with ethyl acetate, dried and concentrated. The crudeproduct was purified with flash column chromatography on silica gel (Eluent: Heptane/ethyl acetate 0 to 20) to provide 1.17 g (100 %) of the title compound.
120737-78-2, As the paragraph descriping shows that 120737-78-2 is playing an increasingly important role.
Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; PTC THERAPEUTICS INC.; DAKKA, Amal; GREEN, Luke; KARP, Gary; NARASIMHAN, Jana; NARYSHKIN, Nikolai; PINARD, Emmanuel; QI, Hongyan; RATNI, Hasane; RISHER, Nicole; WEETALL, Marla; WOLL, Matthew; WO2014/209841; (2014); A2;,
Piperazine – Wikipedia
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