With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57184-25-5,1-(Cyclopropylmethyl)piperazine,as a common compound, the synthetic route is as follows.,57184-25-5
The cis-isomer may be prepared analogously. cis- and trans-4-(4-cyclopropylmethyl-piperazin-1-yl)-cyclohexylamine 9.8 g (33.4 mmol) of 4-dibenzylcyclohexanone is dissolved in 100 mL dichloromethane and stirred with 5.6 g (40 mmol) of N-cyclopropylmethylpiperazine and 8.5 g (40 mmol) of NaBH(OAc)3 for 12 h at RT. Then the mixture is combined with water and potassium carbonate, the org. phase is separated off and dried and the solvent is eliminated in vacuo. The residue is purified on a silica gel column (approx. 50 mL silica gel, approx. 3 L ethyl acetate 95/methanol 5+0.25% conc. ammonia). The desired fractions are evaporated down in vacuo. The faster eluding cis compound crystallises from ethyl acetate. The trans compound is crystallized from ethanol+conc. HCl. Yield: 8.5 g (61%) cis-isomer and 2.2 g (13%) trans-isomer.
The synthetic route of 57184-25-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Boehringer Ingelheim International GmbH; US2006/35903; (2006); A1;,
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