With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
Example 6 To a solution of Compound A (0.3 g, 0.73 mmol) in acetonitrile (6 mL) at room temperature were added diisopropylethylamine (0.5 mL, 2.9 mmol) and cis-2,6-dimethylpiperazine (0.125 g, 1.09 mmol) and the reaction mixture was heated to 80° C. On heating, the reaction mixture became clear and after 15 min commencement of precipitation of solid was observed. Heating was continued for 3 hr and then the reaction mixture was cooled. The solid obtained was collected by filtration, washed with acetonitrile and dried under vacuum. LC/MS: (M+H)+: 489. An NMR spectrum is provided in FIG. 6.Yield: 0.26 g (73percent)., 21655-48-1
The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Sudhakar, Anantha; US2011/105497; (2011); A1;,
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