262368-30-9, N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of methyl (E)-1-acetyl-3-(methoxyphenylmethylene)-oxindole-6-carboxylate of formula 2 (7.03 g), N-(4-aminophenyl)-N,4-dimethyl-1-piperazine acetamide (5.30 g) and methanol (50 ml) was stirred under reflux for 5 h. The bath temperature was reduced to 70C and, at this temperature, a solution of KOH (containing 85% of KOH; 0.13 g) in methanol (2 ml) was added dropwise. The reaction mixture was stirred at 70 to 60C for 30 mm, then itwas left to stand at 20C for 2 h and the crystallization of the product was completed in 2 h at10C. The product was filtered off, washed with glacial methanol twice and air-dried. The yield was 9.71 g (90%) of a yellow powder. HPLC purity 99.86%.
262368-30-9, 262368-30-9 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 21927707, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; ZENTIVA, K.S.; MECA, Ludek; (16 pag.)WO2017/16530; (2017); A1;,
Piperazine – Wikipedia
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