630125-91-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.630125-91-6,4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.
Into a 100-mL round-bottom flask was placed 1-methyl-7-((2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (50 mg, 0.15 mmol), N,N-dimethylformamide (5 mL), 4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline (128 mg, 0.45 mmol), 4-(dimethylamino)pyridine (54 mg, 0.45 mmol), and N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (85 mg, 0.44 mmol). The mixture was stirred at room temperature overnight then concentrated. The residue was applied onto a silica gel column and eluted with ethyl acetate/petroleum ether (1 :5 to 1:0). The resulting product was further purified by prep-HPLC to yield N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-1-methyl-7-((2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-1,2,3,4-tetrahydroquinoline-2-carboxamide (7.5 mg, 8%). (ES, m/z): [M+H]+ = 607.30; NMR (400 MHz, methanol-iri, ppm) d 8.02 (d, J = 2.1Hz, 1H), 7.92 (d, J= 5.7 Hz, 1H), 7.82 (d, J = 8.5 Hz, 1H), 7.75 (d, J= 8.6 Hz, 1H), 7.01 (d, = 8. l Hz, 1H), 6.57 (d, J= 2.3 Hz, 1H), 6.50 (d, = 5.6 Hz, 1H), 6.41 (dd,.7= 8.0, 2.3 Hz, 1H), 6.07 (d, J= 1.1Hz, 1H), 4.11 (t,.7= 4.9 Hz, 1H), 3.66 (s, 2H), 2.95 (s, 3H), 2.77 (m, 2H), 2.55 (m, 9H), 2.54 – 2.41 (m, 2H), 2.39-2.16 (m, 2H), 1.33 (m, 2H), 1.13 (t, J= 12 Hz, 3H).
The synthetic route of 630125-91-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; LYCERA CORPORATION; AICHER, Thomas Daniel; SKALITZKY, Donald J.; TOOGOOD, Peter L.; VANHUIS, Chad A.; (416 pag.)WO2019/200120; (2019); A1;,
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