5625-67-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.
iii 3-Oxo-piperazine-1-carboxylic Acid Tert-Butyl Ester Oxopiperazine (3.38 g, 34 mmol) is dissolved in 20 mL of CH2Cl2. Et3N (9.5 mL, 68 mmol) is added followed by Boc2O (7.4 g, 34 mmol). The solution is allowed to stir at ambient temperature for 3 hours, at which time the reaction is quenched by the addition of brine. The phases are separated and the organic phase is washed with brine, 1 M aqueous KH2PO4 and dried over Na2SO4. The mixture is filtered and concentrated to give iii as a white solid (6.1 g, 30 mmol, 90%). (MS: M+H: 199.0).
5625-67-2 Piperazin-2-one 231360, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Gailunas, Andrea; Tucker, John A.; TenBrink, Ruth; Mickelson, John; US2003/109559; (2003); A1;,
Piperazine – Wikipedia
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