With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.692058-21-2,1-Boc-4-(2,2,2-trifluoroethyl)piperazine,as a common compound, the synthetic route is as follows.
692058-21-2, tert-Butyl 4-(2,2,2-trifluoroethyl)piperazine-l-carboxylate (1.44 g, 5.37 mmol) was dissolved in 15 mL dichloromethane and trifluoroacetic acid (3.67 g, 32.2 mmol) The reaction was carried out for 1 hour at room temperature. After the reaction was completed, the solvent was evaporated under reduced pressure to give the titleCompound.
692058-21-2 1-Boc-4-(2,2,2-trifluoroethyl)piperazine 16748694, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Wang Yong; Zhao Liwen; Ge Chongxun; Huang Yiqiang; Cao Chen; Li Qingqing; Hou Shaohua; (63 pag.)CN108276382; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics