142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
100g of concentrated hydrochloric acid (12mol / L) 250ml round bottom flask was placed in an ice bath, was slowly added 40g of anhydrous piperazine. After addition, the ice bath was removed, the reaction overnight at room temperature, filtered off with suction, the filter cake was placed in an oven dried, the resulting white solid, a piperazine dihydrochloride. 3,4-difluoro-benzoic acid was weighed 7.9g (0.05mol) dissolved in 20ml of dry tetrahydrofuran, was slowly added CDI 8.9g (0.055mol), 4h after the reaction liquid at room temperature through a pressure-equalizing dropping funnel was added dropwise a solution of piperazine dihydrochloride 20g (0.125mol), anhydrous piperazine 10g (0.125mol), 60ml of 14g sodium chloride aqueous solution, at room temperature for 5 hours. After completion of the reaction was suction filtered, the filtrate was evaporated to dryness to remove THF, extracted with ethyl acetate again 10ml, NaOH saturated solution adjusted to pH 10, and the combined organic phase was extracted 3 times with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate overnight, filtered off with suction , rotary evaporation of ethyl acetate, the resulting white crystals which was 1- (3,4-difluoro-benzoyl) piperazine the crude product 5.4g, 48% yield., 142-64-3
The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; XI’AN JIAOTONG UNIVERSITY; ZHANG, JIE; ZHANG, TAO; DONG, JINYUN; PAN, XIAOYAN; HE, LANGCHONG; LU, WEN; WANG, SICEN; SHI, YALING; (19 pag.)CN104262263; (2017); B;,
Piperazine – Wikipedia
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