109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
350 ml of ethanol was added to 155 g (1.547 mol) of N-methylpiperazine. At room temperature (25+/-3 C.), 60 g (0.351 mol) of 4-chloromethylbenzoic acid was added thereto and stirred for 6-7 hours. The reaction was analyzed by HPLC, and then the reaction solution was distilled under reduced pressure to remove ethanol, and 60 ml of 1-butanol was added thereto. The mixture was azeotropically distilled at 70+/-2 C. and concentrated to produce a solid. 600 ml of 2-propanol was added thereto and the mixture was stirred at room temperature (25+/-3 C.) for 30 minutes, stirred under reflux for 15 minutes, and then stirred at room temperature (25+/-3 C.) for 12 hours with slow cooling. The produced precipitate was cooled to 19+/-3 C., stirred for 1 hour and then filtered. The filtrate was washed with 50 ml of cooled 2-propanol and dried in an oven at 60 C., thereby obtaining a white compound of formula (2) (60 g, yield: 72%, purity: 95% or higher).HPLC purity: 99.123% (desmethyl impurity: 0.042%, starting material 0.42%).Thin layer chromatography: Methanol-Dichloromethane (7:5), Rf: 0.2., 109-01-3
109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; BCWORLD PHARM. CO., LTD.; US2012/330014; (2012); A1;,
Piperazine – Wikipedia
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