5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5308-25-8, The inside of a 200 mL flask was placed under a nitrogen atmosphere, and 33.5 mL of toluene and 5.91 g (51.77 mmol) of 1-ethylpiperazine were added and stirred. After cooling to 10 C, 5.00 g (17.26 mmol) of 2-chloro-4- (4-fluorophenyl) -5,6,7,8,9,10-hexahydrocyclo octa [b] pyridine and 1.99 g (20.71 mmol) of sodium-tert-butoxide were added. After reducing the pressure at 100 hPa or less and stirring for 2 minutes, the operation of restoring pressure with nitrogen was repeated 5 times. After adding 0.0775 g (0.345 mmol) of palladium (II) acetate and 0.2715 g (1.035 mmol) of triphenylphosphine, the mixture was depressurized at 100 hPa or less, stirred for 2 minutes, and then pressure restoration with nitrogen was performed three times, and the mixture was stirred under 70 C for 7 hours. The reaction solution was cooled to room temperature, 50 mL of water was added little by little, and after stirring for 30 minutes, the precipitate was removed by filtration using phi 40 mm Kiriyama funnel mounted with 2.50 g of Celite, and washed twice with 10 mL of toluene . The obtained filtrate was transferred to a 300 mL separatory funnel and the aqueous layer was removed (pH 13.0). Water (50 mL) was added to the organic layer, shaken vigorously for 2 minutes, allowed to stand for 10 minutes, and the aqueous layer was removed. This washing operation was repeated until the aqueous layer pH was 9 or less, to obtain a blonanserine toluene solution (49.86 g). Blonanserin content: 5.67 g, reaction yield: 89.12%, HPLC purity: 87.70%.
As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.
Reference：
Patent; DAI NIPPON PRINTING COMPANY LIMITED; YONEYAMA, TAKUYA; ONOZAWA, TAKASHI; (10 pag.)JP2018/127406; (2018); A;,
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