Downstream synthetic route of 4-(4-Methylpiperazin-1-ylmethyl)phenylamine

70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 249; 2 ‘-Chloro-5 ‘-(cyclohexanecarbonyl-amino)-biphenyl-4-carboxylic acid [4-(4-methyl- piperazin- 1 -ylmethyl)-phenyl] -amide; A mixture of 2′-Chloro-5’-(cyclohexanecarbonyl-amino)-biphenyl-4-carboxylic acid(103mg), 4-(4-methyl-pirhoerazin-l-ylmethyl)-phenylamine (59mg) and HBTU (148mg) in dry DMF (1 OmI) containing triethylamine (362mul) was stirred at room temp for 18h.Most of the DMF was evaporated and the residue diluted with water. The resulting solid was collected by filtration. This material was then purified by reverse phase Prep HPLC giving the title compound as a yellow solid (51mg) EPO 1H NMR (DMSO, delta) 1.10-1.81 (1OH, m), 2.17 (3H, s), 2.24-2.28 (9H, m), 3.43 (2H, s),7.29 (2H, d), 7.41-7.61 (2H, m), 7.67 (IH, dd), 7.71-7.81 (2H, m), 8.05 (2H5 d,), 8.83(2H, m), 10.13 (IH, s), 10.36 (IH, s).LCMS- ES+ = 544,546., 70261-82-4

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; ARROW THERAPEUTICS LIMITED; WO2007/31791; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics