70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(E)-(3-(3-(2-(2-Pyridyl))vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole was added to a round bottom flask. 6-yl) thio)propionic acid (50 mg) followed by N,N-dimethylformamide (5 ml), 4-((4-methylpiperazin-1-yl)methyl)aniline (28 mg ),2-(7-oxidized benzotriazole)-N,N,N’,N’-tetramethylureaFluorophosphate (70 mg) and triethylamine (0.05 ml).The reaction system was stirred at room temperature for 14 hours under argon atmosphere.After the reaction is over,The system was evaporated to dryness under reduced pressure.The resultant was diluted with water and extracted with ethyl acetate.Organic phase with water,After washing with saturated brine, it was dried over anhydrous sodium sulfate.The organic phase is filtered,After evaporation under reduced pressure, the crude product was dissolved in anhydrous dichloromethane (5ML),Trifluoroacetic acid (1 mL) was added.The reaction system was stirred at room temperature for 14 hours under argon atmosphere.After the reaction,The system is evaporated to dryness under reduced pressure.The resultant was diluted with water and neutralized to pH > 10 with a saturated sodium hydrogen carbonate solution.The aqueous phase was extracted with ethyl acetate.Organic phase with water,After washing with saturated brine, it was dried over anhydrous sodium sulfate.The organic phase is filtered,After evaporation under reduced pressure, a crude product was obtained.The crude product was purified by column chromatography on silica gel to yield purified compound 134.
70261-82-4, As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.
Reference：
Patent; Chinese Academy Of Sciences Hefei Matter Sciences Institute; Liu Jing; Liu Qingsong; Liu Xuesong; Wang Beilei; Jiang Zongru; Yu Kailin; Chen Cheng; Zou Fengming; Liu Qingwang; Liu Xiaochuan; Wang Wei; Wang Wenliang; Hu Chen; Wang Wenchao; Wang Junjie; Wang Li; (82 pag.)CN109942544; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics