With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.955400-16-5,(S)-tert-Butyl 3-(methoxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,955400-16-5
A mixture of tert-butyl (3S)-3-(methoxymethyl)piperazine-1-carboxylate (633 mg), ethyl acrylate (0.39 mL), and ethanol (1.9 mL) was stirred at 80C for 3 hours under microwave irradiation. The reaction mixture was cooled to room temperature, and then was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain tert-butyl (3S)-4-(3-ethoxy-3-oxopropyl)-3-(methoxymethyl)piperazine-1-carboxylate (444 mg) as an oil.
The synthetic route of 955400-16-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Astellas Pharma Inc.; TAKAHASHI, Taisuke; TANAKA, Hiroaki; AKAIWA, Michinori; NEGORO, Kenji; MIHARA, Hisashi; FUJI, Hideyoshi; TAKAMATSU, Hajime; (133 pag.)EP3196200; (2017); A1;,
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