122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of Z-rnethoxy4–(4-rnethyipiperazin- 1 -yl)aniline (10 g, 452 nunol) in toluene (230 mL) was added Di-tert-butyi dicarbonate (9.87 g, 45.2 mmol). The reaction mixture was stirred at 120 C for 6 hrs and concentrated under reduced pressure. The residue was purified by cohmm chromatography on silica gel (3:97 to 10:90, ammonia solution 7.0 N in methaiiolIdichioromethane) to afford title compound (12.5 g, 86% yield). Rt = 3.23 mm;?H NMR 600 MHz (DMSO-d6) d 7.62 (s, IH), 7.31 (/nc IH), 6.52 (d, .J 2.4 Hz, 1H), 6.38 (dci, J= 2.4 Hz, J= L0 Hz, 1H), 3.72 (s, 3H), 3.04 (in, 4H), 2.39 (in, 4H), 2.17 (s, 3H), 1.38 (r, 9H); MS ni/z: 321.99 [M+ii,., 122833-04-9
122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael; CHOI, Hwan Geun; TAN, Li; WO2015/6492; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics