197638-83-8 1-Boc-4-(4-Formylphenyl)piperazine 2795509, apiperazines compound, is more and more widely used in various fields.
197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
te/f-Butyl 4-(4-(6-chloro-7-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)-3H- imidazo[4,5-iotab]pyridin-2-yl)phenyl)piperazine-1-carboxylate To a mixture of 2-[4-(2-amino-5-chloro-3-nitro-pyridin-4-yl)-piperazin-1-yl]-lambda/-thiazol-2- yl-acetamide (0.048 g, 0.12 mmol) and EtOH (5 ml_) was added tert-butyl 4-(4- formylphenyl)piperazine-1-carboxylate (0.045 g, 0.16 mmol) followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.48 ml_, 0.48 mmol). The reaction mixture was stirred at 80 0C for 18 h, then allowed to cool to room temperature and concentrated in vacuo. The residue was absorbed on silica gel, the free-running powder was placed on a 10 g isolute silica column, and elution with a gradient of methanol (0 to 3%) in ethyl acetate / dichloromethane (v:v; 1 :1 ) afforded the title compound as a pale yellow solid (0.040 g, 53%).1 H-NMR (500 MHz, DMSO-d6) 1.43 (s, 9H, C(CHs)3), 2.77 (br t, 4H), 3.26 (br t obscured by water peak), 3.48 (br t, 4H), and 3.71 (br s, 4H) (piperazine N(CH2)2), 3.40 (s, 2H, NCH2CONH), 7.06 (d, J = 9.3 Hz, 2H) and 8.04 (d, J= 8.2Hz, 2H) (2,6-C6H4 and 3,5-C6H4), 7.23 (d, J = 3.5 Hz, 1 H) and 7.49 (d, J = 3.5 Hz, 1H), (thiazole 4-H, 5-H), 8.05 (s, 1 H, imidazo[4,5-]pyridine 5-H)1 11.87 (br s, 1H, CONH), 13.18 (br s, 1 H, imidazo[4,5-197638-83-8
197638-83-8 1-Boc-4-(4-Formylphenyl)piperazine 2795509, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
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