Some tips on 879896-50-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879896-50-1,2-(4-Methylpiperazin-1-ylmethyl)benzylamine,as a common compound, the synthetic route is as follows.,879896-50-1

Example 111 lambda/-Methoxy-4-methyl-3-[3-[[[2-[(4-methyl-1-piperazinyl)methyl]phenyl]methyl]amino]- 2-oxo-1(2H)-pyrazinyl]-benzamideTo a stirred solution of 3-(3,5-dibromo-2-oxo-2H-pyrazin-1-yl)-4-methyl-benzoic acid, methyl ester (Example 1 b, 0.1 g) in tetrahydrofuran (2 ml.) in a microwave vial was added triethylamine (250 mul_) and 2-[(4-methyl-1-piperazinyl)methyl]-benzenemethanamine (90 mg). The reaction was stirred overnight before the addition of O-methylhydroxylamine hydrochloride (83 mg) and cyclopentylmagnesium bromide (2M in diethyl ether, 2 ml.) dropwise. After stirring for 60 minutes, ethanol (2 ml.) was added followed by the addition of ammonium formate (0.4 g) and 10% palladium on carbon (40 mg). The reaction mixture was heated within a microwave for 30 minutes at 100C before being cooled to room temperature, filtered and washed with ethanol. The filtrate was concentrated in vacuo. Purification by preparative HPLC (Gemini column, 0.1 % trifluroacetic acid: acetonitrile eluent) afforded the title compound (13 mg). MS: APCI(+ve) 477 (M+H+).1H NMR delta(DMSO-d6, 400MHz) 7.77 (1 H, d), 7.67 (1 H, s), 7.51 (1 H, d), 7.41 (1 H, d), 7.33 – 7.27 (3H, m), 6.90 (1 H, d), 6.75 (1 H, d), 4.72 (1 H, d), 4.62 (1 H, d), 3.80 – 3.69 (2H, m), 3.69 (3H, s), 3.44 – 3.25 (4H, m), 2.70 (3H, s), 2.50 – 2.35 (2H, m), 2.12 (3H, s).

The synthetic route of 879896-50-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/1132; (2008); A1;,
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