2031-23-4, 1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 3 4,6-Diamino-2-[3-(4-methyl-1-piperazinyl)propylthio]-5-(2-methoxybenzyl)pyrimidine trihydrochloride To a suspension of 6.0 g (20 mmoles) of 4,6-diamino-2-mercapto-5-(2-methoxybenzyl)pyrimidine potassium salt, 2.76 g (20 mmoles) of potassium carbonate and 0.33 g (2 mmoles) of potassium iodide in 100 ml of methyl alcohol, 5.0 g (20 mmoles) of 1-(3-chloropropyl)-4-methylpiperazine dihydrochloride are added, and the reaction mixture is boiled for 20 hours. The mixture is allowed to cool to room temperature, the inorganic salts are filtered, the filtrate is evaporated under reduced pressure, the oil obtained is crystallized from water, the crystalline substance is filtered and dried. The base obtained is reacted in ethyl alcohol with 3 equivalents of hydrogen chloride using isopropanol containing hydrogen chloride. Thus, 5.5 g (53.7%) of the title product are obtained. M.p.: above 280 C. Analysis: for C20H33Cl3N6OS (511.95) calculated: C, 46.92%; H, 6.50%; N, 16.42%; S, 6.26%; Cl, (ionic) 20.78%; found: C, 46.31%; H, 6.54%; N, 16.14%; S, 6.26%; Cl, (ionic) 20.44%., 2031-23-4
The synthetic route of 2031-23-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; EGIS Gyogyszergyar Rt.; US6469168; (2002); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics