1217599-13-7, (R)-1-Boc-2-Isobutylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a vial containing (R) -tert-butyl 2-isobutylpiperazine-1-carboxylate (17-a) (50.8 mg, 0.210 mmol, commerically available from Matrix Scientific, Cairo, Egypt) , were added compound 10-d (48.3 mg, 0.220 mmol) , DMF (2.0 mL) and DIEA (100 mul, 0.57 mmol) . The mixture was stirred at RT for 19 h. The mixture was then filtered and purified by preparative, reverse-phase HPLC (eluting with ACN/water with 0.1%TFA) to afford (R) -tert-butyl 4- (5-cyano-2- (1-methyl-1H-pyrazol-4-yl) pyrimidin-4-yl) -2-isobutylpiperazine-1-carboxylate (17-b) as the TFA salt. MS (ESI) Calc?d for C22H32N7O2[M+1]+, 426; found, 426., 1217599-13-7
The synthetic route of 1217599-13-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; MCGOWAN, Meredeth A.; KATZ, Jason D.; CHRISTOPHER, Matthew; ZHOU, Hua; WITTER, David James; LI, Chaomin; LAMPE, John; METHOT, Joey L.; ACHAB, Abdelghani A.; XU, Shimin; FRADERA, Xavier; (123 pag.)WO2019/119206; (2019); A1;,
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